RAD9A Antibody – Mouse Monoclonal

This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

RAD9A: a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. Possesses a 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. Forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for Rad9.

Protein type: Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: 3'-5' exonuclease activity; enzyme binding; histone deacetylase binding; protein binding; protein kinase binding; SH3 domain binding

Biological Process: DNA damage checkpoint; DNA replication; DNA replication checkpoint; intra-S DNA damage checkpoint; response to DNA damage stimulus