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CBR1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475070

Entrez Summary: Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds.This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene… More details

$525 / 0.1 mL +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CBR1, Monoclonal Antibody
Full Product Name
Anti-CBR1 Mouse mAb
Product Gene Name
anti-CBR1 antibody
Product Synonym Gene Name
CBR; hCBR1; SDR21C1
Product Synonym Names
15 hydroxyprostaglandin dehydrogenase [NADP]; 15-hydroxyprostaglandin dehydrogenase [NADP]; Carbonyl reductase [NADPH] 1; CBR 1; CBR1; CBR1_HUMAN; CRN; NADPH dependent carbonyl reductase 1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9 ketoreductase; Prostaglandin 9-ketoreductase; Prostaglandin E (2) 9 reductase; Prostaglandin-E (2) 9-reductase; SDR21C1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2C9-B12-C4
Host
Mouse
Source: Human
Species Reactivity
Human
Sensitivity
This antibody detects endogenous levels of CBR1 and does not cross-react with related proteins.
Form/Format
Purified mouse monoclonal in PBS (pH 7.4)containing with 0.2% sodium azide, 50% glycerol.
Purity/Purification
Affinity Purified
Concentration
1.3mg/ml (lot specific)
Molecular Weight
30
OMIM
J04056 mRNA
3D Structure
ModBase 3D Structure for P16152
Immunogen
Purified recombinant human CBR1 protein fragments expressed in E Coli
Sequence Similarities
Belongs to the short-chain dehydrogenases/reductases (SDR) family
Subunit Structure
Monomer
Subcellular Location
Cytoplasm
Applications Tested/Suitable for anti-CBR1 antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-CBR1 antibody
WB: 1:1000
ICC: 1:100

Western Blot (WB) of anti-CBR1 antibody

Western blot detection of CBR1 in Hela, A431 and MDA-MB-468 cell lysates using CBR1 mouse mAb (1:1000 diluted).Predicted band size:30KDa, Observed band size:30KDa.
Mouse Anti-CBR1 Monoclonal Antibody – Cat# MBS475070

Immunocytochemistry (ICC) of anti-CBR1 antibody

Immunocytochemistry stain of Hela using CBR1 mouse mAb (1:100).
Mouse Anti-CBR1 Monoclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS475070

Other Notes

Small volumes of anti-CBR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CBR1 purchase

MBS475070 is an antibody targeting CBR1. Also known as Anti-CBR1 Mouse mAb. Reactive in Human. Host: Mouse
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for CBR1. It may not necessarily be applicable to this product.

NCBI GI #
557948119
NCBI GeneID
873
NCBI Accession #
NP_001273718.1
UniProt Primary Accession #
P16152
UniProt Secondary Accession #
Q3LHW8; B2RBZ7; B4DFK7
UniProt Related Accession #
P16152
GenBank Nucleotide #
NM_001757
NCBI Official Full Name
carbonyl reductase
NCBI Official Synonym Full Names
carbonyl reductase 1
NCBI Official Symbol
CBR1
NCBI Official Synonym Symbols
CBR; hCBR1; SDR21C1
UniProt Protein Name
Carbonyl reductase [NADPH] 1
UniProt Synonym Protein Names
15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197); NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase (EC:1.1.1.189); Short chain dehydrogenase/reductase family 21C member 1
Protein Family
Carbonyl reductase
UniProt Gene Name
CBR1
UniProt Synonym Gene Names
CBR; CRN; SDR21C1
NCBI Protein Information
carbonyl reductase [NADPH] 1

NCBI Summary for CBR1

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
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UniProt Comments for CBR1

CBR1: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: EC 1.1.1.184; EC 1.1.1.189; EC 1.1.1.197; Lipid Metabolism - arachidonic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 21q22.12

Cellular Component: cytosol

Molecular Function: carbonyl reductase (NADPH) activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity

Biological Process: cyclooxygenase pathway; drug metabolic process; epithelial cell differentiation; vitamin K metabolic process
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Research Articles on CBR1

1. These results suggest that CR1 induces apoptosis by activating the caspase pathway via binding to TNFR1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CBR1 antibody

 Reference Product  PubMed Publications
 AKR1A1 antibody  >7 publications with CBR1 and AKR1A1
 AKR1B10 antibody  >2 publications with CBR1 and AKR1B10
 PTGES2 antibody  >2 publications with CBR1 and PTGES2
 PTGES antibody  >2 publications with CBR1 and PTGES
 GCH1 antibody  >1 publications with CBR1 and GCH1
 SPR antibody  >1 publications with CBR1 and SPR

Pathways associated with anti-CBR1 antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram

Diseases associated with anti-CBR1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >10 publications with CBR1 and Breast Neoplasms
 Liver Diseases Antibodies  >7 publications with CBR1 and Liver Diseases
 Liver Neoplasms Antibodies  >5 publications with CBR1 and Liver Neoplasms
 Fibrosis Antibodies  >4 publications with CBR1 and Fibrosis
 Necrosis Antibodies  >3 publications with CBR1 and Necrosis
 Heart Diseases Antibodies  >3 publications with CBR1 and Heart Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with CBR1 and Carcinoma, Hepatocellular
 Weight Loss Antibodies  >2 publications with CBR1 and Weight Loss
 Inflammation Antibodies  >2 publications with CBR1 and Inflammation
 Fever Antibodies  >2 publications with CBR1 and Fever

Organs/Tissues associated with anti-CBR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >22 publications with CBR1 and Liver
 Blood Antibodies  >11 publications with CBR1 and Blood
 Brain Antibodies  >11 publications with CBR1 and Brain
 Uterus Antibodies  >8 publications with CBR1 and Uterus
 Heart Antibodies  >6 publications with CBR1 and Heart
 Ovary Antibodies  >5 publications with CBR1 and Ovary
 Muscle Antibodies  >5 publications with CBR1 and Muscle
 Lung Antibodies  >5 publications with CBR1 and Lung
 Nerve Antibodies  >4 publications with CBR1 and Nerve
 Pancreas Antibodies  >3 publications with CBR1 and Pancreas
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