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CD54 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475072

Entrez Summary: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.… More details

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Product Overview

Online Datasheet in PDF
Product Name
CD54, Monoclonal Antibody
Full Product Name
Anti-CD54 (ICAM-1) Mouse mAb
Product Gene Name
anti-CD54 antibody
Product Synonym Gene Name
icam1; BB2; CD54; P3.58
Product Synonym Names
Antigen identified by monoclonal; BB2; BB 2; BB2; CD 54; CD_antigen=CD54; CD54; CD54 antigen; Cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM 1; ICAM-1; ICAM1; ICAM1_HUMAN; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; Major group rhinovirus receptor; MALA 2; MALA2; MyD 10; MyD10; P3.58; Surface antigen of activated B cells; Surface antigen of activated B cells, BB2
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
1C7-A8-D6
Host
Mouse
Source: Human
Species Reactivity
Human
Sensitivity
This antibody detects endogenous levels of CD54 (ICAM-1) and does not cross-react with related proteins.
Form/Format
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%, glycerol
Purity/Purification
Affinity Purified
Concentration
1mg/ml (lot specific)
Molecular Weight
96
OMIM
X06990 mRNA
3D Structure
ModBase 3D Structure for P05362
Immunogen
Purified recombinant human CD54 (ICAM-1) protein fragments expressed in E Coli.
Sequence Similarities
Belongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Subunit Structure
Homodimer Probable. Interacts with human herpesvirus 8 MIR2 protein Probable. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.
Subcellular Location
Membrane; Single-pass type I membrane protein.
Applications Tested/Suitable for anti-CD54 antibody
Western Blot (WB)
Application Notes for anti-CD54 antibody
WB: 1:1000

Western Blot (WB) of anti-CD54 antibody

Western blot detection of CD54 (ICAM-1) in Raji and SW480 cell lysates and using CD54 (ICAM-1) mouse mAb (1:1000 diluted).Predicted band size: 58KDa.Observed band size: 96KDa.
Mouse Anti-CD54 Monoclonal Antibody – Cat# MBS475072

Other Notes

Small volumes of anti-CD54 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD54 purchase

MBS475072 is an antibody targeting CD54. Also known as Anti-CD54 (ICAM-1) Mouse mAb. Reactive in Human. Host: Mouse
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for CD54. It may not necessarily be applicable to this product.

NCBI GI #
167466198
NCBI GeneID
3383
NCBI Accession #
NP_000192.2
UniProt Primary Accession #
P05362
UniProt Secondary Accession #
Q5NKV7; Q96B50; B2R6M3
UniProt Related Accession #
P05362
GenBank Nucleotide #
NM_000201
NCBI Official Full Name
intercellular adhesion molecule 1
NCBI Official Synonym Full Names
intercellular adhesion molecule 1
NCBI Official Symbol
ICAM1
NCBI Official Synonym Symbols
BB2; CD54; P3.58
UniProt Protein Name
Intercellular adhesion molecule 1
UniProt Synonym Protein Names
Major group rhinovirus receptor; CD_antigen: CD54
Protein Family
Intercellular adhesion molecule
UniProt Gene Name
ICAM1
UniProt Synonym Gene Names
ICAM-1
NCBI Protein Information
intercellular adhesion molecule 1

NCBI Summary for CD54

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

UniProt Comments for CD54

ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cell surface; extracellular space; focal adhesion; integral to plasma membrane; membrane; plasma membrane

Molecular Function: integrin binding; protein binding; receptor activity; transmembrane receptor activity

Biological Process: adhesion to host; cell adhesion; extracellular matrix organization and biogenesis; heterophilic cell adhesion; leukocyte adhesion; leukocyte migration; membrane to membrane docking; positive regulation of cellular extravasation; regulation of immune response; regulation of leukocyte mediated cytotoxicity; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; virion attachment, binding of host cell surface receptor

Disease: Malaria, Susceptibility To
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Research Articles on CD54

1. The results suggest that the genetic polymorphism in ICAM-1 rs5498 single nucleotide polymorphisms with genotype AG and GG is associated with hepatocellular carcinoma risk among smokers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD54 antibody

 Reference Product  PubMed Publications
 ITGB2 antibody  >860 publications with CD54 and ITGB2
 ITGAL antibody  >467 publications with CD54 and ITGAL
 ITGAM antibody  >423 publications with CD54 and ITGAM
 CD44 antibody  >356 publications with CD54 and CD44
 ITGAX antibody  >134 publications with CD54 and ITGAX
 IL6 antibody  >115 publications with CD54 and IL6
 SELE antibody  >59 publications with CD54 and SELE
 HLA-B antibody  >28 publications with CD54 and HLA-B
 DIF antibody  >3 publications with CD54 and DIF

Pathways associated with anti-CD54 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with anti-CD54 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5074 publications with CD54 and Inflammation
 Necrosis Antibodies  >4440 publications with CD54 and Necrosis
 Cardiovascular Diseases Antibodies  >3300 publications with CD54 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1309 publications with CD54 and Atherosclerosis
 Reperfusion Injury Antibodies  >810 publications with CD54 and Reperfusion Injury
 Myocardial Ischemia Antibodies  >740 publications with CD54 and Myocardial Ischemia
 Kidney Diseases Antibodies  >717 publications with CD54 and Kidney Diseases
 Liver Diseases Antibodies  >511 publications with CD54 and Liver Diseases
 Asthma Antibodies  >475 publications with CD54 and Asthma
 Hypertension Antibodies  >474 publications with CD54 and Hypertension

Organs/Tissues associated with anti-CD54 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11071 publications with CD54 and Blood
 Vascular Antibodies  >8225 publications with CD54 and Vascular
 Lung Antibodies  >1634 publications with CD54 and Lung
 Heart Antibodies  >1179 publications with CD54 and Heart
 Skin Antibodies  >1167 publications with CD54 and Skin
 Liver Antibodies  >1108 publications with CD54 and Liver
 Kidney Antibodies  >1098 publications with CD54 and Kidney
 Brain Antibodies  >1085 publications with CD54 and Brain
 Muscle Antibodies  >959 publications with CD54 and Muscle
 Embryonic Tissue Antibodies  >755 publications with CD54 and Embryonic Tissue
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