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CSK Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475092

MBS475092 is an antibody targeting CSK. Also known as Anti-CSK Mouse mAb. Reactive in Human, Rat. Host: MouseSource: Human. More details

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Product Documentation
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CSK, Monoclonal Antibody
Full Product Name
Anti-CSK Mouse mAb
Product Gene Name
anti-CSK antibody
Product Synonym Names
C SRC; C SRC kinase; C src Tyrosine Kinase; C-SRC kinase; c-src tyrosine kinase; Csk A; CSK; CSK_HUMAN; CYTOPLASMIC TYROSINE KINASE; EC 2.7.10.2; MGC112926; MGC117393; MGC154049; P60 Src; Protein tyrosine kinase CYL; Protein-tyrosine kinase CYL; Proto oncogene tyrosine protein kinase; Tyrosine protein kinase CSK; Tyrosine protein kinase CSK; Tyrosine-protein kinase CSK; zgc:154049
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
2B4-C6-A10
Host
Mouse
Source: Human
Species Reactivity
Human, Rat
Sensitivity
This antibody detects endogenous levels of CSK and does not cross-react with related proteins.
Form/Format
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl)with 0.2% sodium azide, 0.1mg/mlBSA and 50% glycerol.
Purity/Purification
Affinity Purified
Concentration
1mg/ml (lot specific)
Molecular Weight
50
OMIM
X60114 mRNA
3D Structure
ModBase 3D Structure for P41240
Immunogen
Purified recombinant human CSK protein fragments expressed in E Coli.
Sequence Similarities
Belongs to the protein kinase superfamily.Tyr protein kinase family.CSK subfamily.Contains 1 protein kinase domain.Contains 1 SH2 domain.Contains 1 SH3 domain.
Subunit Structure
Homodimer (via SH3-domain). Interacts with PTPN8 By similarity. Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases. Interacts with SRCIN1. Interacts with RHOH. Interacts (via SH2 domain) with SCIMP.
Subcellular Location
Cytoplasm. Cell membrane.

Product Categories/Family for anti-CSK antibody

Signal Transduction; Protein Phosphorylation; Tyrosine Kinases; Src Family
Applications Tested/Suitable for anti-CSK antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-CSK antibody
WB: 1:1000
ICC: 1:50

Western Blot (WB) of anti-CSK antibody

Western blot detection of CSK in C6 and Jurkat cell lysates using CSK mouse mAb (1:1000 diluted).Predicted band size:50KDa.Observed band size:50KDa.
Mouse Anti-CSK Monoclonal Antibody – Cat# MBS475092

Immunocytochemistry (ICC) of anti-CSK antibody

Immunocytochemistry staining of C6 cells fixed by anhydrous methanol for 2 h at -20 degree C and using anti-CSK mouse mAb (dilution 1:50).
Mouse Anti-CSK Monoclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS475092

Other Notes

Small volumes of anti-CSK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CSK. It may not necessarily be applicable to this product.

NCBI GI #
187475373
NCBI GeneID
1445
NCBI Accession #
NP_001120662.1
UniProt Primary Accession #
P41240
UniProt Secondary Accession #
Q2M3N2; Q6FGZ6
UniProt Related Accession #
P41240
GenBank Nucleotide #
NM_001127190
NCBI Official Full Name
tyrosine-protein kinase CSK
NCBI Official Synonym Full Names
CSK, non-receptor tyrosine kinase
NCBI Official Symbol
CSK
UniProt Protein Name
Tyrosine-protein kinase CSK
UniProt Synonym Protein Names
C-Src kinase; Protein-tyrosine kinase CYL
Protein Family
Chloroplast sensor kinase
UniProt Gene Name
CSK
NCBI Protein Information
tyrosine-protein kinase CSK

UniProt Comments for CSK

CSK: a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development.

Protein type: Csk family; EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; plasma membrane

Molecular Function: identical protein binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; protein binding; protein C-terminus binding; protein-tyrosine kinase activity; receptor binding

Biological Process: cell differentiation; cell migration; central nervous system development; epidermal growth factor receptor signaling pathway; innate immune response; negative regulation of Golgi to plasma membrane protein transport; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cytokine production; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
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Research Articles on CSK

1. Our results do not support association between PTPN22/CSK and Henoch-Schonlein purpura

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CSK antibody

 Reference Product  PubMed Publications
 SRC antibody  >1280 publications with CSK and SRC
 FYN antibody  >150 publications with CSK and FYN
 LYN antibody  >97 publications with CSK and LYN
 LCK antibody  >95 publications with CSK and LCK
 PAG1 antibody  >51 publications with CSK and PAG1
 PTK2 antibody  >48 publications with CSK and PTK2
 TLR3 antibody  >26 publications with CSK and TLR3
 PXN antibody  >25 publications with CSK and PXN
 HCK antibody  >22 publications with CSK and HCK
 FGR antibody  >20 publications with CSK and FGR

Pathways associated with anti-CSK antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 GAB1 Signalosome Pathway antibodies  GAB1 Signalosome Pathway Diagram

Diseases associated with anti-CSK antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >172 publications with CSK and Inflammation
 Carcinoma Antibodies  >155 publications with CSK and Carcinoma
 Heart Diseases Antibodies  >102 publications with CSK and Heart Diseases
 Necrosis Antibodies  >100 publications with CSK and Necrosis
 Kidney Diseases Antibodies  >96 publications with CSK and Kidney Diseases
 Breast Neoplasms Antibodies  >80 publications with CSK and Breast Neoplasms
 Hypertension Antibodies  >66 publications with CSK and Hypertension
 Drug Toxicity Antibodies  >64 publications with CSK and Drug Toxicity
 Adenocarcinoma Antibodies  >61 publications with CSK and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >58 publications with CSK and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-CSK antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >564 publications with CSK and Blood
 Vascular Antibodies  >188 publications with CSK and Vascular
 Brain Antibodies  >185 publications with CSK and Brain
 Bone Antibodies  >172 publications with CSK and Bone
 Kidney Antibodies  >169 publications with CSK and Kidney
 Lung Antibodies  >110 publications with CSK and Lung
 Heart Antibodies  >105 publications with CSK and Heart
 Liver Antibodies  >86 publications with CSK and Liver
 Bone Marrow Antibodies  >78 publications with CSK and Bone Marrow
 Skin Antibodies  >69 publications with CSK and Skin
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