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c-JUN Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475094

Entrez Summary: This gene is the putative transforming gene of avian sarcoma virus 17.It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression.This gene is… More details

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Product Overview

Online Datasheet in PDF
Product Name
c-JUN, Monoclonal Antibody
Full Product Name
Anti-c-JUN Mouse mAb
Product Gene Name
anti-c-JUN antibody
Product Synonym Gene Name
AP1; AP-1; c-Jun.
Product Synonym Names
Activator Protein 1; AP 1; AP1; cJun; Enhancer Binding Protein AP1; Jun Activation Domain Binding Protein; JUN; Jun oncogene; JUN protein; Jun proto oncogene; JUN_HUMAN; JUNC; Oncogene JUN; p39; Proto oncogene c jun; Proto oncogene cJun; Proto-oncogene c-jun; Transcription Factor AP 1; Transcription factor AP-1; Transcription Factor AP1; V jun avian sarcoma virus 17 oncogene homolog; V jun sarcoma virus 17 oncogene homolog (avian); V jun sarcoma virus 17 oncogene homolog; V-jun avian sarcoma virus 17 oncogene homolog; vJun Avian Sarcoma Virus 17 Oncogene Homolog
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3B3-A5-D7-F7
Host
Mouse
Source: Human
Sensitivity
Transfected
Form/Format
Purified mouse monoclonal in PBS (pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity Purified
Concentration
3.0mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C short term. Store at -20 degree C long term. Avoid freeze/thaw cycle.
Molecular Weight
43/48 kDa
OMIM
J04111 Genomic DNA
3D Structure
ModBase 3D Structure for P05412
Antibody Type
Primary antibody
Conjugation
Unconjugated
Modification
Unmodification
Immunogen
Purified recombinant human c-JUN protein fragments expressed in E Coli.
Sequence Similarities
Belongs to the bZIP family. Jun subfamily.Contains 1 bZIP (basic-leucine zipper) domain.
Subunit Structure
Heterodimer with either FOS or BATF3 or ATF7.The ATF7/JUN heterodimer is essential for ATF7 transactivation activity.Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA by similarity.Interacts with HIVEP3 and MYBBP1A by similarity.Interacts with SP1, SPIB and TCF20.Interacts with COPS5; the interaction leads indirectly to its phosphorylation.Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site.The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta.Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex.Interacts with methylated RNF187.Binds to HIPK3.
Subcellular Location
Nucleus.
Applications Tested/Suitable for anti-c-JUN antibody
Western Blot (WB)
Application Notes for anti-c-JUN antibody
WB: 1:1000

Western Blot (WB) of anti-c-JUN antibody

Western blot detection of c-JUN in CHO-K1 transfected by PEGFP-C1-c-JUN (A)and CHO-K1 cell lysate (B)cell lysate using c-JUN mouse mAb (1:1000 diluted).Predicted band size:43/48KDa.Observed band size:43/48KDa.
Mouse Anti-c-JUN Monoclonal Antibody – Cat# MBS475094

Other Notes

Small volumes of anti-c-JUN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for c-JUN purchase

MBS475094 is an antibody targeting c-JUN. Also known as Anti-c-JUN Mouse mAb. Host: Mouse
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for c-JUN. It may not necessarily be applicable to this product.

NCBI GI #
4758616
NCBI GeneID
3725
NCBI Accession #
NP_002219.1
UniProt Primary Accession #
P05412
UniProt Secondary Accession #
Q6FHM7; Q96G93
UniProt Related Accession #
P05412
GenBank Nucleotide #
NM_002228
NCBI Official Full Name
transcription factor AP-1
NCBI Official Synonym Full Names
Jun proto-oncogene, AP-1 transcription factor subunit
NCBI Official Symbol
JUN
NCBI Official Synonym Symbols
AP1; AP-1; c-Jun
UniProt Protein Name
Transcription factor AP-1
UniProt Synonym Protein Names
Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
Protein Family
C-Jun-amino-terminal kinase-interacting protein
UniProt Gene Name
JUN
UniProt Synonym Gene Names
AP1
NCBI Protein Information
transcription factor AP-1

NCBI Summary for c-JUN

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
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UniProt Comments for c-JUN

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
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Research Articles on c-JUN

1. A novel tribasic Golgi export signal directs cargo protein interaction with activated Rab11 and AP-1-dependent Golgi-plasma membrane trafficking.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-c-JUN antibody

 Reference Product  PubMed Publications
 FOS antibody  >7724 publications with c-JUN and FOS
 MAPK3 antibody  >1743 publications with c-JUN and MAPK3
 ITCH antibody  >1555 publications with c-JUN and ITCH
 STAT3 antibody  >1154 publications with c-JUN and STAT3
 SP1 antibody  >1117 publications with c-JUN and SP1
 CYP19A1 antibody  >1089 publications with c-JUN and CYP19A1
 JUNB antibody  >1007 publications with c-JUN and JUNB
 BRCA1 antibody  >838 publications with c-JUN and BRCA1
 MAPK8 antibody  >753 publications with c-JUN and MAPK8
 HIF1A antibody  >692 publications with c-JUN and HIF1A

Pathways associated with anti-c-JUN antibody

 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram

Diseases associated with anti-c-JUN antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >212671 publications with c-JUN and Neoplasms
 Nervous System Diseases Antibodies  >169822 publications with c-JUN and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >153114 publications with c-JUN and Cardiovascular Diseases
 Brain Diseases Antibodies  >80019 publications with c-JUN and Brain Diseases
 Heart Diseases Antibodies  >75539 publications with c-JUN and Heart Diseases
 Pain Antibodies  >48946 publications with c-JUN and Pain
 Liver Diseases Antibodies  >40433 publications with c-JUN and Liver Diseases
 Inflammation Antibodies  >37550 publications with c-JUN and Inflammation
 Kidney Diseases Antibodies  >34758 publications with c-JUN and Kidney Diseases
 Hypertension Antibodies  >31808 publications with c-JUN and Hypertension

Organs/Tissues associated with anti-c-JUN antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >287449 publications with c-JUN and Blood
 Brain Antibodies  >118368 publications with c-JUN and Brain
 Heart Antibodies  >92781 publications with c-JUN and Heart
 Vascular Antibodies  >83532 publications with c-JUN and Vascular
 Bone Antibodies  >80771 publications with c-JUN and Bone
 Liver Antibodies  >74113 publications with c-JUN and Liver
 Muscle Antibodies  >72042 publications with c-JUN and Muscle
 Lung Antibodies  >55937 publications with c-JUN and Lung
 Kidney Antibodies  >54571 publications with c-JUN and Kidney
 Skin Antibodies  >51525 publications with c-JUN and Skin
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