PI3 Kinase P85 Beta (pik3r2) Antibody – Mouse Monoclonal

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]

PIK3R2: regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Its SH2 domains interacts with the YTHM motif of phosphorylated INSR in vitro. Defects in PIK3R1 are a cause of severe insulin resistance. Four alternatively spliced isoforms have been described.

Protein type: Kinase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: cytosol; nucleus; phosphoinositide 3-kinase complex

Molecular Function: 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity; GTPase activator activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein heterodimerization activity; protein phosphatase binding; receptor tyrosine kinase binding

Biological Process: cell glucose homeostasis; cellular response to insulin stimulus; insulin receptor signaling pathway; leukocyte migration; phosphatidylinositol biosynthetic process; phosphoinositide 3-kinase cascade; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of autophagy; regulation of phosphoinositide 3-kinase activity; regulation of phosphoinositide 3-kinase cascade; regulation of small GTPase mediated signal transduction; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway

Disease: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus Syndrome 1