Mouse Anti-AKR1B1 Monoclonal Antibody – Cat# MBS475240

Western blot detection of AKR1B1 in C6, 3T3, Jurkat and Hela cell lysates using AKR1B1 mouse mAb (1:1000 diluted). Predicted band size:36KDa. Observed band size:36KDa.

AKR1B1 Antibody – Mouse Monoclonal

Name: AKR1B1 Antibody; Monoclonal; Mouse; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS475240
Price: 525 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475240

Entrez Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AKR1B1, Monoclonal Antibody

Full Product Name

Anti-AKR1B1 Mouse mAb

Product Gene Name

anti-AKR1B1 antibody

Product Synonym Gene Name

AR; ADR; ALR2; ALDR1

Product Synonym Names

ADR; AKR1B 1; Akr1b1; Aldehyde reductase 1; Aldehyde reductase; Aldo keto reductase family 1, member B1; Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1 (aldose reductase); Aldose reductase; aldr 1; ALDR_HUMAN; ALDR1; ALR2; AR; Lii5 2 CTCL tumor antigen; Low Km aldose reductase; MGC1804

Clonality

Monoclonal

Isotype

IgG1

Clone Number

4G9-B6-F6

Host

Mouse
Source: Human

Species Reactivity

Human, Mouse, Rat

Sensitivity

This antibody detects endogenous levels of AKR1B1 and does not cross-react with related proteins.

Form/Format

PBS (pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

Purity/Purification

Affinity Purified

Concentration

4.2mg/ml (lot specific)

Molecular Weight

OMIM

J04795 mRNA

3D Structure

ModBase 3D Structure for P15121

Immunogen

Purified recombinant human AKR1B1 protein fragments expressed in E Coli.

Sequence Similarities

Belongs to the aldo/keto reductase family.

Subunit Structure

Monomer.

Subcellular Location

Cytoplasm.

Product Categories/Family for anti-AKR1B1 antibody

Signal Transduction; Metabolism; Energy Metabolism; Metabolism Pathways and Processes; Metabolic signaling pathways; Energy transfer pathways; Energy Metabolism

Applications Tested/Suitable for anti-AKR1B1 antibody

Western Blot (WB)

Application Notes for anti-AKR1B1 antibody

WB: 1:1000

Other Notes

Small volumes of anti-AKR1B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKR1B1 purchase

MBS475240 is an antibody targeting AKR1B1. Also known as Anti-AKR1B1 Mouse mAb. Reactive in Human, Mouse, Rat. Host: Mouse
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1B1. It may not necessarily be applicable to this product.

NCBI GI #

4502049

NCBI GeneID

231

NCBI Accession #

NP_001619.1

UniProt Primary Accession #

P15121

UniProt Secondary Accession #

Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9; B2R8N3

UniProt Related Accession #

P15121

GenBank Nucleotide #

NM_001628.2

NCBI Official Full Name

aldose reductase isoform 1

NCBI Official Synonym Full Names

aldo-keto reductase family 1 member B

NCBI Official Symbol

AKR1B1

NCBI Official Synonym Symbols

AR; ADR; ALR2; ALDR1

UniProt Protein Name

Aldose reductase

UniProt Synonym Protein Names

Aldehyde reductase; Aldo-keto reductase family 1 member B1

Protein Family

Aldose reductase

UniProt Gene Name

AKR1B1

UniProt Synonym Gene Names

ALDR1; AR

NCBI Protein Information

aldose reductase

NCBI Summary for AKR1B1

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

UniProt Comments for AKR1B1

AKR1B1: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Belongs to the aldo/keto reductase family.

Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - pyruvate; EC 1.1.1.21; Lipid Metabolism - glycerolipid; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; glyceraldehyde oxidoreductase activity

Biological Process: C21-steroid hormone biosynthetic process; carbohydrate metabolic process; fructose biosynthetic process; response to stress

Research Articles on AKR1B1

1. -106T allele of AKR1B1 C-106T polymorphism may be associated with increased risk for essential hypertension in Chinese Han population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-AKR1B1 antibody

Products by Pathway	Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
Fructose And Mannose Metabolism Pathway antibodies	Fructose And Mannose Metabolism Pathway Diagram
Galactose Metabolism Pathway antibodies	Galactose Metabolism Pathway Diagram
Galactose Metabolism Pathway antibodies	Galactose Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies	Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram
Pentose And Glucuronate Interconversions Pathway antibodies	Pentose And Glucuronate Interconversions Pathway Diagram

Diseases associated with anti-AKR1B1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>14 publications with AKR1B1 and Neoplasms
Inflammation Antibodies	>8 publications with AKR1B1 and Inflammation
Kidney Diseases Antibodies	>7 publications with AKR1B1 and Kidney Diseases
Cataract Antibodies	>7 publications with AKR1B1 and Cataract
Necrosis Antibodies	>6 publications with AKR1B1 and Necrosis
Nervous System Diseases Antibodies	>4 publications with AKR1B1 and Nervous System Diseases
Carcinoma Antibodies	>4 publications with AKR1B1 and Carcinoma
Heart Diseases Antibodies	>3 publications with AKR1B1 and Heart Diseases
Breast Neoplasms Antibodies	>3 publications with AKR1B1 and Breast Neoplasms
Proteinuria Antibodies	>3 publications with AKR1B1 and Proteinuria

Organs/Tissues associated with anti-AKR1B1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>14 publications with AKR1B1 and Blood
Eye Antibodies	>11 publications with AKR1B1 and Eye
Lung Antibodies	>10 publications with AKR1B1 and Lung
Liver Antibodies	>9 publications with AKR1B1 and Liver
Kidney Antibodies	>9 publications with AKR1B1 and Kidney
Uterus Antibodies	>7 publications with AKR1B1 and Uterus
Heart Antibodies	>7 publications with AKR1B1 and Heart
Muscle Antibodies	>7 publications with AKR1B1 and Muscle
Vascular Antibodies	>6 publications with AKR1B1 and Vascular
Adrenal Gland Antibodies	>5 publications with AKR1B1 and Adrenal Gland