• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

p90RSK Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475303

Entrez Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated… More details

$525 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
p90RSK, Monoclonal Antibody
Full Product Name
Anti-p90RSK Mouse mAb
Product Gene Name
anti-p90RSK antibody
Product Synonym Gene Name
rps6ka1; RPS6KA1; RSK; HU-1; RSK1; p90Rsk; MAPKAPK1A
Product Synonym Names
90 kDa ribosomal protein S6 kinase 1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1; dJ590P13.1; EC 2.7.11.1; HU 1; HU1; KS6A1_HUMAN; MAP kinase activated protein kinase 1a; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; MAPKAPK1A; MGC79981; Mitogen-activated protein kinase-activated protein kinase 1A; OTTHUMP00000004113; p90 RSK1; p90-RSK 1; p90rsk; p90RSK1; p90S6K; pp90RSK1; Ribosomal protein S6 kinase 90kD 1; Ribosomal protein S6 kinase 90kD polypeptide 1; Ribosomal protein S6 kinase 90kDa polypeptide 1; Ribosomal protein S6 kinase alpha 1; Ribosomal protein S6 kinase alpha-1; Ribosomal protein S6 kinase polypeptide 1; Ribosomal S6 kinase 1; RPS6K1 alpha; rps6ka; Rps6ka1; RSK 1; RSK 1 p90; RSK; RSK-1; RSK1; S6K alpha 1; S6K-alpha-1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
6B9-D6-F8
Host
Mouse
Source: Human
Species Reactivity
Human, Mouse, Monkey
Sensitivity
This antibody detects endogenous levels of p90RSK and does not cross-react with related proteins.
Form/Format
Purified mouse monoclonal antibody in PBS (pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Purity/Purification
Affinity Purified
Concentration
3.02mg/ml (lot specific)
Molecular Weight
90
OMIM
L07597 mRNA
3D Structure
ModBase 3D Structure for Q15418
Immunogen
Purified recombinant human p90RSK protein fragments expressed in E Coli.
Sequence Similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 protein kinase domains.
Subunit Structure
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1.
Applications Tested/Suitable for anti-p90RSK antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-p90RSK antibody
WB: 1:1000

Western Blot (WB) of anti-p90RSK antibody

Western blot detection of p90RSK in COS7, 3T3, Jurkat, Hela and A549 cell lysates using p90RSK mouse mAb (dilution 1:1000).Predicted band size:90KDa.Observed band size:90KDa.
Mouse Anti-p90RSK Monoclonal Antibody – Cat# MBS475303

Immunoprecipitation (IP) of anti-p90RSK antibody

Immunoprecipitation analysis of Hela cell lysates using p90RSK mouse mAb.
Mouse Anti-p90RSK Monoclonal Antibody, Immunoprecipitation (IP) – Cat# MBS475303

Other Notes

Small volumes of anti-p90RSK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for p90RSK purchase

MBS475303 is an antibody targeting p90RSK. Also known as Anti-p90RSK Mouse mAb. Reactive in Human, Mouse, Monkey. Host: Mouse
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for p90RSK. It may not necessarily be applicable to this product.

NCBI GI #
55743134
NCBI GeneID
6195
NCBI Accession #
NP_001006666.1
UniProt Primary Accession #
Q15418
UniProt Secondary Accession #
Q5SVM5; Q5SVM8; Q5SVM9; Q96C05; Q9BQK2; A6NGG4; A8K9K7; B2RDY8; B7Z5J0; E9PRI4
UniProt Related Accession #
Q15418
GenBank Nucleotide #
NM_002953
NCBI Official Full Name
ribosomal protein S6 kinase alpha-1 isoform b
NCBI Official Synonym Full Names
ribosomal protein S6 kinase A1
NCBI Official Symbol
RPS6KA1
NCBI Official Synonym Symbols
RSK; HU-1; RSK1; p90Rsk; MAPKAPK1A
UniProt Protein Name
Ribosomal protein S6 kinase alpha-1
UniProt Synonym Protein Names
90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1; RSK-1
UniProt Gene Name
RPS6KA1
UniProt Synonym Gene Names
MAPKAPK1A; RSK1; S6K-alpha-1; p90-RSK 1; p90RSK1; p90S6K; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1
NCBI Protein Information
ribosomal protein S6 kinase alpha-1

NCBI Summary for p90RSK

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for p90RSK

p90RSK: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.

Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; RSK subfamily; Translation

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: caspase inhibitor activity; kinase activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity

Biological Process: negative regulation of apoptosis; negative regulation of caspase activity; positive regulation of cell differentiation; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription in response to stress; regulation of translation in response to stress; signal transduction
Show more

Research Articles on p90RSK

1. The p90RSK has an essential role in promoting tumor growth and proliferation in non-small cell lung cancer (NSCLC). BID may serve as an alternative cancer treatment in NSCLC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-p90RSK antibody

 Reference Product  PubMed Publications
 MTOR antibody  >74 publications with p90RSK and MTOR
 MAPK1 antibody  >28 publications with p90RSK and MAPK1
 MAPK3 antibody  >27 publications with p90RSK and MAPK3
 BAD antibody  >8 publications with p90RSK and BAD
 FOS antibody  >5 publications with p90RSK and FOS
 TSC2 antibody  >5 publications with p90RSK and TSC2
 yopM antibody  >4 publications with p90RSK and yopM
 EEF2K antibody  >3 publications with p90RSK and EEF2K
 CREB1 antibody  >3 publications with p90RSK and CREB1
 MITF antibody  >3 publications with p90RSK and MITF

Pathways associated with anti-p90RSK antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CREB Phosphorylation Pathway antibodies  CREB Phosphorylation Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cytoplasmic Ribosomal Proteins Pathway antibodies  Cytoplasmic Ribosomal Proteins Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram

Diseases associated with anti-p90RSK antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >32 publications with p90RSK and Neoplasms
 Insulin Resistance Antibodies  >18 publications with p90RSK and Insulin Resistance
 Inflammation Antibodies  >13 publications with p90RSK and Inflammation
 Disease Models, Animal Antibodies  >10 publications with p90RSK and Disease Models, Animal
 Hypertrophy Antibodies  >10 publications with p90RSK and Hypertrophy
 Liver Diseases Antibodies  >9 publications with p90RSK and Liver Diseases
 Cardiovascular Diseases Antibodies  >7 publications with p90RSK and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >7 publications with p90RSK and Breast Neoplasms
 Hyperplasia Antibodies  >6 publications with p90RSK and Hyperplasia
 Fatty Liver Antibodies  >4 publications with p90RSK and Fatty Liver

Organs/Tissues associated with anti-p90RSK antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >43 publications with p90RSK and Muscle
 Blood Antibodies  >26 publications with p90RSK and Blood
 Liver Antibodies  >22 publications with p90RSK and Liver
 Brain Antibodies  >21 publications with p90RSK and Brain
 Heart Antibodies  >19 publications with p90RSK and Heart
 Lung Antibodies  >8 publications with p90RSK and Lung
 Connective Tissue Antibodies  >7 publications with p90RSK and Connective Tissue
 Vascular Antibodies  >7 publications with p90RSK and Vascular
 Embryonic Tissue Antibodies  >5 publications with p90RSK and Embryonic Tissue
 Bone Antibodies  >5 publications with p90RSK and Bone
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000