Mouse Anti-CK-MM Monoclonal Antibody – Cat# MBS475323

Indirect ELISA assay for anti-CK-MM mouse mAb.CKBB as control antigen. Antigen coating concentration: 4ug/ml.

CK-MM Antibody – Mouse Monoclonal

Name: CK-MM Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS475323
Price: 525 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475323

Entrez Summary: There are 3 isoenzymes of creatine kinase (CK)-BB, MM, and MB. The primary source of CKMB is myocardium, although it is also found in skeletal muscle. CKMB levels increase with myocardial damage. Extreme elevations of CKMB can also be… More details

$525 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CK-MM, Monoclonal Antibody

Full Product Name

Anti-CK-MM Mouse mAb

Product Gene Name

anti-CK-MM antibody

Product Synonym Gene Name

ckmm; CKMM; M-CK.

Product Synonym Names

CKM; CKMM; Creatine kinase M; Creatine kinase M chain; Creatine kinase M type; Creatine kinase M-type; Creatine kinase muscle; Creatine kinase, muscle type; KCRM_HUMAN; M-CK; MCK; Muscle creatine kinase

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

6A12-C8

Host

Mouse
Source: Human

Species Reactivity

Human

Sensitivity

This antibody detects Human CK-MM.

Form/Format

PBS (pH 7.4) containing with 0.03% Proclin300.

Purity/Purification

Affinity Purified

Concentration

4.84mg/ml (lot specific)

Molecular Weight

43,101 Da

OMIM

M14780 mRNA

3D Structure

ModBase 3D Structure for P06732

Immunogen

Purified recombinant human CK-MM protein expressed in E Coli.

Sequence Similarities

Belongs to the ATP:guanido phosphotransferase family. Contains 1 phosphagen kinase C-terminal domain. Contains 1 phosphagen kinase N-terminal domain.

Subunit Structure

Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.

Subcellular Location

Cytoplasm.

Applications Tested/Suitable for anti-CK-MM antibody

ELISA (EIA)

Other Notes

Small volumes of anti-CK-MM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CK-MM purchase

MBS475323 is an antibody targeting CK-MM. Also known as Anti-CK-MM Mouse mAb. Reactive in Human. Host: Mouse
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for CK-MM. It may not necessarily be applicable to this product.

NCBI GI #

21536288

NCBI GeneID

1158

NCBI Accession #

NP_001815.2

UniProt Primary Accession #

P06732

UniProt Secondary Accession #

Q96QL9

UniProt Related Accession #

P06732

GenBank Nucleotide #

NM_001824

NCBI Official Full Name

creatine kinase M-type

NCBI Official Synonym Full Names

creatine kinase, M-type

NCBI Official Symbol

CKM

NCBI Official Synonym Symbols

CKMM; M-CK

UniProt Protein Name

Creatine kinase M-type

UniProt Synonym Protein Names

Creatine kinase M chain; M-CK

UniProt Gene Name

CKM

UniProt Synonym Gene Names

CKMM

NCBI Protein Information

creatine kinase M-type

NCBI Summary for CK-MM

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]

UniProt Comments for CK-MM

CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family.

Protein type: Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytosol

Molecular Function: creatine kinase activity; protein binding

Biological Process: creatine metabolic process

Research Articles on CK-MM

1. A positive association was found between PANSS-total and sCK [serum creatine kinase] in SzA [schizoaffective disorder] and BP-I; however, PANSS-positive scores correlated with sCK only in SzA. Serum CK may serve as a biomarker for affective exacerbation rather than psychosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CK-MM antibody

Reference Product	PubMed Publications
CKB antibody	>13 publications with CK-MM and CKB

Pathways associated with anti-CK-MM antibody

Products by Pathway	Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Creatine Metabolism Pathway antibodies	Creatine Metabolism Pathway Diagram
Creatine Pathway antibodies	Creatine Pathway Diagram
Creatine Pathway antibodies	Creatine Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Regulation Of Retinoblastoma Protein Pathway antibodies	Regulation Of Retinoblastoma Protein Pathway Diagram
Urea Cycle And Metabolism Of Amino Groups Pathway antibodies	Urea Cycle And Metabolism Of Amino Groups Pathway Diagram
Creatine-phosphate Biosynthesis Pathway antibodies	Creatine-phosphate Biosynthesis Pathway Diagram

Diseases associated with anti-CK-MM antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>12 publications with CK-MM and Neoplasms
Heart Diseases Antibodies	>11 publications with CK-MM and Heart Diseases
Myocardial Infarction Antibodies	>6 publications with CK-MM and Myocardial Infarction
Kidney Diseases Antibodies	>5 publications with CK-MM and Kidney Diseases
Lung Neoplasms Antibodies	>4 publications with CK-MM and Lung Neoplasms
Ischemia Antibodies	>4 publications with CK-MM and Ischemia
Cardiomyopathies Antibodies	>3 publications with CK-MM and Cardiomyopathies
Liver Diseases Antibodies	>3 publications with CK-MM and Liver Diseases
Brain Diseases Antibodies	>3 publications with CK-MM and Brain Diseases
Neoplasm Metastasis Antibodies	>3 publications with CK-MM and Neoplasm Metastasis

Organs/Tissues associated with anti-CK-MM antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>46 publications with CK-MM and Muscle
Heart Antibodies	>24 publications with CK-MM and Heart
Brain Antibodies	>8 publications with CK-MM and Brain
Kidney Antibodies	>7 publications with CK-MM and Kidney
Lung Antibodies	>6 publications with CK-MM and Lung
Liver Antibodies	>6 publications with CK-MM and Liver
Embryonic Tissue Antibodies	>3 publications with CK-MM and Embryonic Tissue
Vascular Antibodies	>3 publications with CK-MM and Vascular
Nerve Antibodies	>2 publications with CK-MM and Nerve
Eye Antibodies	>2 publications with CK-MM and Eye