Rabbit Anti-CD79A Polyclonal Antibody – Cat# MBS475554

Western blot analysis of extracts from Human Tonsil cell lysates using CD79A Rabbit pAb (1:200 diluted).Predicted band size:25kDa.Observed band size:45-55kDa.

CD79A Antibody – Rabbit Polyclonal

Name: CD79A Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS475554
Price: 530 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475554

Entrez Summary: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD79A, Polyclonal Antibody

Full Product Name

Anti-CD79A Rabbit pAb

Product Gene Name

anti-CD79A antibody

Product Synonym Gene Name

IGA; MB-1

Product Synonym Names

B lymphocyte-specific MB1 protein; B-cell antigen receptor complex-associated protein alpha chain; CD 79a; CD79a; CD79a antigen (immunoglobulin-associated alpha); CD79A antigen; CD79a molecule, immunoglobulin-associated alpha; CD79A_HUMAN; Ig alpha; Ig-alpha; IGA; IgM-alpha; Immunoglobulin-associated alpha; Ly54; MB-1 membrane glycoprotein; MB1; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein

Clonality

Polyclonal

Isotype

Host

Rabbit

Species Reactivity

Human

Form/Format

10mM PBS with 0.02% sodium azide, 50% glycerol.

Purity/Purification

Affinity Purified

Molecular Weight

45-59

OMIM

S46706 mRNA

3D Structure

ModBase 3D Structure for P11912

Immunogen

CFRKRWQNEKLGLD

Sequence Similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 ITAM domain

Subunit Structure

Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-210, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity (By similarity).

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Applications Tested/Suitable for anti-CD79A antibody

Western Blot (WB)

Application Notes for anti-CD79A antibody

WB: 1:200

Other Notes

Small volumes of anti-CD79A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD79A purchase

MBS475554 is an antibody targeting CD79A. Also known as Anti-CD79A Rabbit pAb. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD79A. It may not necessarily be applicable to this product.

NCBI GI #

4502685

NCBI GeneID

973

NCBI Accession #

NP_001774.1

UniProt Primary Accession #

P11912

UniProt Secondary Accession #

Q53FB8; A0N775

UniProt Related Accession #

P11912

GenBank Nucleotide #

NM_001783

NCBI Official Full Name

B-cell antigen receptor complex-associated protein alpha chain isoform 1

NCBI Official Synonym Full Names

CD79a molecule

NCBI Official Symbol

CD79A

NCBI Official Synonym Symbols

IGA; MB-1

UniProt Protein Name

B-cell antigen receptor complex-associated protein alpha chain

UniProt Synonym Protein Names

Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD_antigen: CD79a

Protein Family

B-cell antigen receptor complex-associated protein

UniProt Gene Name

CD79A

UniProt Synonym Gene Names

IGA; MB1

NCBI Protein Information

B-cell antigen receptor complex-associated protein alpha chain

NCBI Summary for CD79A

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

UniProt Comments for CD79A

Ig-alpha: an integral membrane protein that associates with surface immunoglobulin B lymphocyte antigen receptor multimeric complex. Surface Ig non-covalently associates with 2 other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. Two alternatively spliced isoforms have been described.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: B cell receptor complex; cytoplasm; external side of plasma membrane; integral to plasma membrane; lipid raft; multivesicular body; plasma membrane

Molecular Function: protein binding

Biological Process: B cell activation; B cell differentiation; B cell proliferation; B cell receptor signaling pathway

Disease: Agammaglobulinemia 3, Autosomal Recessive

Research Articles on CD79A

1. Data show that Bruton tyrosine kinase (BTK)inhibitor Ibrutinib augments MALT lymphoma associated translocation protein (MALT1) inhibition by S-Mepazine in CD79 antigen mutant activated B cell-subtype (ABC) of diffuse large B cell lymphoma (DLBCL).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD79A antibody

Reference Product	PubMed Publications
CD79B antibody	>570 publications with CD79A and CD79B
CD5 antibody	>153 publications with CD79A and CD5
CD19 antibody	>134 publications with CD79A and CD19
SYK antibody	>34 publications with CD79A and SYK
LYN antibody	>22 publications with CD79A and LYN
FYN antibody	>10 publications with CD79A and FYN
BLNK antibody	>10 publications with CD79A and BLNK
BLK antibody	>5 publications with CD79A and BLK
IGHM antibody	>4 publications with CD79A and IGHM
PTPN6 antibody	>4 publications with CD79A and PTPN6

Pathways associated with anti-CD79A antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway antibodies	Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
BCR Signaling Pathway antibodies	BCR Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Primary Immunodeficiency Pathway antibodies	Primary Immunodeficiency Pathway Diagram
Primary Immunodeficiency Pathway antibodies	Primary Immunodeficiency Pathway Diagram
Signaling By The B Cell Receptor (BCR) Pathway antibodies	Signaling By The B Cell Receptor (BCR) Pathway Diagram

Diseases associated with anti-CD79A antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>738 publications with CD79A and Neoplasms
Lymphoma Antibodies	>641 publications with CD79A and Lymphoma
Skin Neoplasms Antibodies	>78 publications with CD79A and Skin Neoplasms
Neoplasms, Experimental Antibodies	>69 publications with CD79A and Neoplasms, Experimental
Cardiovascular Diseases Antibodies	>47 publications with CD79A and Cardiovascular Diseases
Inflammation Antibodies	>41 publications with CD79A and Inflammation
Hyperplasia Antibodies	>38 publications with CD79A and Hyperplasia
Liver Diseases Antibodies	>38 publications with CD79A and Liver Diseases
Necrosis Antibodies	>37 publications with CD79A and Necrosis
Multiple Myeloma Antibodies	>36 publications with CD79A and Multiple Myeloma

Organs/Tissues associated with anti-CD79A antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>530 publications with CD79A and Blood
Lymph Node Antibodies	>206 publications with CD79A and Lymph Node
Lymph Antibodies	>194 publications with CD79A and Lymph
Spleen Antibodies	>82 publications with CD79A and Spleen
Liver Antibodies	>77 publications with CD79A and Liver
Lung Antibodies	>47 publications with CD79A and Lung
Intestine Antibodies	>40 publications with CD79A and Intestine
Thymus Antibodies	>30 publications with CD79A and Thymus
Mouth Antibodies	>21 publications with CD79A and Mouth
Heart Antibodies	>19 publications with CD79A and Heart