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SMYD2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475570

Entrez Summary: SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008] More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
SMYD2, Polyclonal Antibody
Full Product Name
Anti-SMYD2 Rabbit pAb
Product Gene Name
anti-SMYD2 antibody
Product Synonym Gene Name
KMT3C; HSKM-B; ZMYND14
Product Synonym Names
Histone methyltransferase SMYD2; HSKM B; HSKM-B; HSKMB; KMT3C; Lysine N-methyltransferase 3C; MGC119305; N lysine methyltransferase SMYD2; N-lysine methyltransferase SMYD2; SET and MYND domain containing 2; SET and MYND domain containing protein 2; SET and MYND domain-containing protein 2; Smyd2; SMYD2_HUMAN; Zinc finger MYND domain containing 14; ZMYND14
Clonality
Polyclonal
Isotype
Ig
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
10mM PBS with 0.02% sodium azide, 50% glycerol.
Purity/Purification
Affinity Purified
Molecular Weight
50
OMIM
AF226053 mRNA
3D Structure
ModBase 3D Structure for Q9NRG4
Immunogen
CEFESHLDKLDNEKKDLIQSD
Sequence Similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily. Contains 1 MYND-type zinc finger. Contains 1 SET domain.
Subunit Structure
Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1 (By similarity). Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1.
Applications Tested/Suitable for anti-SMYD2 antibody
Western Blot (WB)
Application Notes for anti-SMYD2 antibody
WB: 1:1000

Western Blot (WB) of anti-SMYD2 antibody

Western blot detection of SMYD2 in Jurkat, HCT116, 3T3, Hela and C6 cell lysates using SMYD2 Rabbit pAb (1:1000 diluted).Predicted band size:50kDa.Observed band size:50kDa.
Rabbit Anti-SMYD2 Polyclonal Antibody – Cat# MBS475570

Other Notes

Small volumes of anti-SMYD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMYD2 purchase

MBS475570 is an antibody targeting SMYD2. Also known as Anti-SMYD2 Rabbit pAb. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SMYD2. It may not necessarily be applicable to this product.

NCBI GI #
188035871
NCBI GeneID
56950
NCBI Accession #
NP_064582.2
UniProt Primary Accession #
Q9NRG4
UniProt Secondary Accession #
Q4V765; Q5VSH9; Q96AI4; B2R9P9; I6L9H7
UniProt Related Accession #
Q9NRG4
GenBank Nucleotide #
NM_020197
NCBI Official Full Name
N-lysine methyltransferase SMYD2
NCBI Official Synonym Full Names
SET and MYND domain containing 2
NCBI Official Symbol
SMYD2
NCBI Official Synonym Symbols
KMT3C; HSKM-B; ZMYND14
UniProt Protein Name
N-lysine methyltransferase SMYD2
UniProt Synonym Protein Names
HSKM-B; Histone methyltransferase SMYD2 (EC:2.1.1.43); Lysine N-methyltransferase 3C; SET and MYND domain-containing protein 2
Protein Family
N-lysine methyltransferase
UniProt Gene Name
SMYD2
UniProt Synonym Gene Names
KMT3C
NCBI Protein Information
N-lysine methyltransferase SMYD2

NCBI Summary for SMYD2

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]

UniProt Comments for SMYD2

SMYD2: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB. Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1. Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1. Expression is repressed by CEBPA.

Protein type: EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 1q32.3

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: histone lysine N-methyltransferase activity (H3-K36 specific); histone-lysine N-methyltransferase activity; lysine N-methyltransferase activity; p53 binding; protein binding; protein-lysine N-methyltransferase activity

Biological Process: negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation; regulation of DNA damage response, signal transduction by p53 class mediator
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Research Articles on SMYD2

1. Study reveals a collection of 10 enriched sequence motifs in Kme1 sites that were identified upon SMYD2 overexpression which were also downregulated in response to SMYD2 knockdown. These findings suggest that these motifs reflect the substrate specificity of SMYD2 in esophageal squamous cell carcinoma cell line.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SMYD2 antibody

 Reference Product  PubMed Publications
 TP53 antibody  >6 publications with SMYD2 and TP53
 SETD7 antibody  >3 publications with SMYD2 and SETD7
 RB1 antibody  >2 publications with SMYD2 and RB1
 L3MBTL1 antibody  >1 publications with SMYD2 and L3MBTL1
 HSP90AB1 antibody  >1 publications with SMYD2 and HSP90AB1

Pathways associated with anti-SMYD2 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram

Diseases associated with anti-SMYD2 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4 publications with SMYD2 and Breast Neoplasms
 Mental Disorders Antibodies  >1 publications with SMYD2 and Mental Disorders
 Liver Neoplasms Antibodies  >1 publications with SMYD2 and Liver Neoplasms
 Inflammation Antibodies  >1 publications with SMYD2 and Inflammation
 Necrosis Antibodies  >1 publications with SMYD2 and Necrosis

Organs/Tissues associated with anti-SMYD2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >8 publications with SMYD2 and Muscle
 Heart Antibodies  >7 publications with SMYD2 and Heart
 Embryonic Tissue Antibodies  >3 publications with SMYD2 and Embryonic Tissue
 Lung Antibodies  >3 publications with SMYD2 and Lung
 Brain Antibodies  >3 publications with SMYD2 and Brain
 Lymph Node Antibodies  >2 publications with SMYD2 and Lymph Node
 Blood Antibodies  >2 publications with SMYD2 and Blood
 Lymph Antibodies  >2 publications with SMYD2 and Lymph
 Liver Antibodies  >1 publications with SMYD2 and Liver
 Bone Marrow Antibodies  >1 publications with SMYD2 and Bone Marrow
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