Dynamin-1 (DNM1) Antibody – Mouse Monoclonal

DYN1: a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain.

Protein type: EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle

Chromosomal Location of Human Ortholog: 3p12

Cellular Component: cytoplasm; Golgi apparatus; membrane coat; mitochondrial membrane; myelin sheath; photoreceptor inner segment; plasma membrane; protein complex; synapse; synaptic vesicle

Molecular Function: D2 dopamine receptor binding; GTPase activity; identical protein binding; microtubule binding; nitric-oxide synthase binding; protein binding; protein C-terminus binding; protein complex binding; protein dimerization activity; protein kinase binding

Biological Process: adult locomotory behavior; endocytosis; endosome organization and biogenesis; G-protein coupled receptor internalization; mitochondrial fission; protein tetramerization; receptor internalization; receptor-mediated endocytosis; sensory perception of sound; synaptic transmission, GABAergic