MYST1 Antibody – Mouse Monoclonal

This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

MYST1: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Belongs to the MYST (SAS/MOZ) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Acetyltransferase; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: histone acetyltransferase complex; nucleoplasm; nucleus

Molecular Function: acetyltransferase activity; histone acetyltransferase activity; histone acetyltransferase activity (H4-K16 specific); methylated histone residue binding; protein binding; transcription factor binding

Biological Process: histone acetylation; myeloid cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of autophagy