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AMACR Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475764

Entrez Summary: AMACR (alpha-methylacyl-CoA racemase) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in prostatic… More details

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Product Overview

Product Name
AMACR, Monoclonal Antibody
Full Product Name
Anti-AMACR Mouse mAb
Product Gene Name
anti-AMACR antibody
Product Synonym Gene Name
RACE
Product Synonym Names
RACE
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
2A10F3
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
42
OMIM
AJ130733 mRNA
3D Structure
ModBase 3D Structure for Q9UHK6
Immunogen
Purified recombinant fragment of human AMACR expressed in E Coli.
Applications Tested/Suitable for anti-AMACR antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Western Blot (WB) of anti-AMACR antibody

Western blot analysis using AMACR mouse mAb against Jurkat (1) and LNCaP (2) cell lysate.
Mouse Anti-AMACR Monoclonal Antibody – Cat# MBS475764

Immunofluorescence (IF) of anti-AMACR antibody

Confocal immunofluorescence analysis of LNCaP cells using AMACR mouse mAb (green). Red
Mouse Anti-AMACR Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS475764

Immunohistochemistry (IHC) of anti-AMACR antibody

Immunohistochemical analysis of paraffin-embedded human normal prostate tissues (left) and prostate adenocarcinoma tissues (right), showing cytoplasmic localization using AMACR mouse mAb with DAB staining.
Mouse Anti-AMACR Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS475764

Immunohistochemistry (IHC) of anti-AMACR antibody

Immunohistochemical analysis of paraffin-embedded human brain cerebellum using AMACR mouse mAb.
Mouse Anti-AMACR Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS475764

Other Notes

Small volumes of anti-AMACR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AMACR purchase

MBS475764 is an antibody targeting AMACR. Also known as Anti-AMACR Mouse mAb. Reactive in Human, Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for AMACR. It may not necessarily be applicable to this product.

NCBI GI #
42822893
NCBI GeneID
23600
NCBI Accession #
NP_976316.1
UniProt Primary Accession #
Q9UHK6
UniProt Secondary Accession #
O43673; Q3KT79; Q96GH1; Q9Y3Q1; A5YM47; B8Y916; B8Y918; F8W9N1
UniProt Related Accession #
Q9UHK6
GenBank Nucleotide #
NM_203382.2
NCBI Official Full Name
alpha-methylacyl-CoA racemase isoform 2
NCBI Official Synonym Full Names
alpha-methylacyl-CoA racemase
NCBI Official Symbol
AMACR
NCBI Official Synonym Symbols
RM; RACE; CBAS4; P504S; AMACRD
UniProt Protein Name
Alpha-methylacyl-CoA racemase
UniProt Synonym Protein Names
2-methylacyl-CoA racemase
Protein Family
Alpha-methylacyl-CoA racemase
UniProt Gene Name
AMACR
NCBI Protein Information
alpha-methylacyl-CoA racemase

NCBI Summary for AMACR

This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
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UniProt Comments for AMACR

AMACR: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. Belongs to the CaiB/BaiF CoA-transferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 5.1.99.4; Isomerase; Lipid Metabolism - primary bile acid biosynthesis; Mitochondrial

Chromosomal Location of Human Ortholog: 5p13.2

Cellular Component: cytoplasm; mitochondrion; peroxisomal matrix; peroxisome

Molecular Function: alpha-methylacyl-CoA racemase activity; receptor binding

Biological Process: bile acid biosynthetic process; bile acid metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase

Disease: Alpha-methylacyl-coa Racemase Deficiency; Bile Acid Synthesis Defect, Congenital, 4
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Research Articles on AMACR

1. AMACR is expressed in most of the chordomas but only in a minority of chondrosarcomas. AMACR may serve as IHC marker of chordoma with differentiating ability comparable to that of beta-catenin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AMACR antibody

 Reference Product  PubMed Publications
 OR51E2 antibody  >3 publications with AMACR and OR51E2
 OR51E1 antibody  >1 publications with AMACR and OR51E1
 SP1 antibody  >1 publications with AMACR and SP1
 ACOX2 antibody  >1 publications with AMACR and ACOX2
 ACOX3 antibody  >1 publications with AMACR and ACOX3

Pathways associated with anti-AMACR antibody

 Products by Pathway  Pathway Diagram
 Beta-oxidation Of Pristanoyl-CoA Pathway antibodies  Beta-oxidation Of Pristanoyl-CoA Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Peroxisomal Lipid Metabolism Pathway antibodies  Peroxisomal Lipid Metabolism Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram

Diseases associated with anti-AMACR antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >222 publications with AMACR and Carcinoma
 Prostatic Neoplasms Antibodies  >210 publications with AMACR and Prostatic Neoplasms
 Adenocarcinoma Antibodies  >178 publications with AMACR and Adenocarcinoma
 Kidney Neoplasms Antibodies  >64 publications with AMACR and Kidney Neoplasms
 Kidney Diseases Antibodies  >59 publications with AMACR and Kidney Diseases
 Adenoma Antibodies  >37 publications with AMACR and Adenoma
 Hyperplasia Antibodies  >37 publications with AMACR and Hyperplasia
 Colorectal Neoplasms Antibodies  >29 publications with AMACR and Colorectal Neoplasms
 Neoplasm Metastasis Antibodies  >14 publications with AMACR and Neoplasm Metastasis
 Precancerous Conditions Antibodies  >12 publications with AMACR and Precancerous Conditions

Organs/Tissues associated with anti-AMACR antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >243 publications with AMACR and Prostate
 Kidney Antibodies  >67 publications with AMACR and Kidney
 Blood Antibodies  >41 publications with AMACR and Blood
 Bladder Antibodies  >16 publications with AMACR and Bladder
 Liver Antibodies  >15 publications with AMACR and Liver
 Lung Antibodies  >13 publications with AMACR and Lung
 Lymph Antibodies  >10 publications with AMACR and Lymph
 Intestine Antibodies  >9 publications with AMACR and Intestine
 Lymph Node Antibodies  >9 publications with AMACR and Lymph Node
 Muscle Antibodies  >8 publications with AMACR and Muscle
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