AXL Antibody – Mouse Monoclonal

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Axl family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cell surface; extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: phosphatidylserine binding; protein binding; protein-tyrosine kinase activity

Biological Process: cell maturation; entry of virus into host cell; negative regulation of interferon-gamma production; phagocytosis; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of natural killer cell differentiation; positive regulation of pinocytosis; signal transduction; vascular endothelial growth factor receptor signaling pathway