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ISL1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475917

Entrez Summary: ISL1 (ISL1 transcription factor, LIM/homeodomain) is a member of the LIM/homeodomain family of transcription factors. It binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
ISL1, Monoclonal Antibody
Full Product Name
Anti-ISL1 Mouse mAb
Product Gene Name
anti-ISL1 antibody
Product Synonym Gene Name
Isl-1; ISLET1
Product Synonym Names
Isl-1; ISLET1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
1B1
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
39
OMIM
S70721 mRNA
3D Structure
ModBase 3D Structure for P61371
Immunogen
Purified recombinant fragment of human ISL1 expressed in E Coli.
Applications Tested/Suitable for anti-ISL1 antibody
Western Blot (WB), Immunocytochemistry (ICC)

Western Blot (WB) of anti-ISL1 antibody

Western blot analysis using ISL1 mouse mAb against full-length ISL1 (aa1-349)-hIgGFc transfected HEK293 cell lysate (1).
Mouse Anti-ISL1 Monoclonal Antibody – Cat# MBS475917

Immunofluorescence (IF) of anti-ISL1 antibody

Confocal immunofluorescence analysis of HEK293 cells trasfected with full-length ISL1-hIgGFc using ISL1 mouse mAb (green). Blue
Mouse Anti-ISL1 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS475917

Other Notes

Small volumes of anti-ISL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ISL1 purchase

MBS475917 is an antibody targeting ISL1. Also known as Anti-ISL1 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ISL1. It may not necessarily be applicable to this product.

NCBI GI #
115387114
NCBI GeneID
3670
NCBI Accession #
NP_002193.2
UniProt Primary Accession #
P61371
UniProt Secondary Accession #
P20663; P47894
UniProt Related Accession #
P61371
GenBank Nucleotide #
NM_002202.2
NCBI Official Full Name
insulin gene enhancer protein ISL-1
NCBI Official Synonym Full Names
ISL LIM homeobox 1
NCBI Official Symbol
ISL1
NCBI Official Synonym Symbols
Isl-1; ISLET1
UniProt Protein Name
Insulin gene enhancer protein ISL-1
Protein Family
Insulin gene enhancer protein
UniProt Gene Name
ISL1
UniProt Synonym Gene Names
Islet-1
NCBI Protein Information
insulin gene enhancer protein ISL-1

NCBI Summary for ISL1

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
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UniProt Comments for ISL1

ISL1: Binds to one of the cis-acting domain of the insulin gene enhancer.

Protein type: Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 5q11.1

Cellular Component: nucleoplasm

Molecular Function: bHLH transcription factor binding; estrogen receptor binding; ligand-dependent nuclear receptor binding; protein binding

Biological Process: mesenchymal cell differentiation; negative regulation of estrogen receptor signaling pathway; negative regulation of inflammatory response; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; neuron fate specification; pancreas development; peripheral nervous system neuron axonogenesis; pharyngeal system development; positive regulation of angiogenesis; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of insulin secretion; positive regulation of interferon-gamma production; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-1 beta production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; sensory system development; spinal cord motor neuron differentiation; trigeminal nerve development; ventricular cardiac muscle morphogenesis
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Research Articles on ISL1

1. ISL-1 is widely expressed in Olfactory neuroblastoma tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ISL1 antibody

 Reference Product  PubMed Publications
 MEF2C antibody  >17 publications with ISL1 and MEF2C
 SHH antibody  >15 publications with ISL1 and SHH
 BMP4 antibody  >12 publications with ISL1 and BMP4
 FGF10 antibody  >10 publications with ISL1 and FGF10
 INS antibody  >8 publications with ISL1 and INS

Pathways associated with anti-ISL1 antibody

 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Incretin Synthesis, Secretion, And Inactivation Pathway antibodies  Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway antibodies  Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway Diagram

Diseases associated with anti-ISL1 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >36 publications with ISL1 and Heart Diseases
 Cardiovascular Diseases Antibodies  >35 publications with ISL1 and Cardiovascular Diseases
 Congenital Abnormalities Antibodies  >31 publications with ISL1 and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >24 publications with ISL1 and Heart Defects, Congenital
 Cardiovascular Abnormalities Antibodies  >22 publications with ISL1 and Cardiovascular Abnormalities
 Nervous System Diseases Antibodies  >10 publications with ISL1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >5 publications with ISL1 and Lung Neoplasms
 Fibrosis Antibodies  >4 publications with ISL1 and Fibrosis
 Neoplasm Metastasis Antibodies  >4 publications with ISL1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >4 publications with ISL1 and Breast Neoplasms

Organs/Tissues associated with anti-ISL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >120 publications with ISL1 and Embryonic Tissue
 Muscle Antibodies  >101 publications with ISL1 and Muscle
 Pancreas Antibodies  >62 publications with ISL1 and Pancreas
 Brain Antibodies  >53 publications with ISL1 and Brain
 Eye Antibodies  >43 publications with ISL1 and Eye
 Lung Antibodies  >11 publications with ISL1 and Lung
 Stomach Antibodies  >5 publications with ISL1 and Stomach
 Intestine Antibodies  >3 publications with ISL1 and Intestine
 Kidney Antibodies  >3 publications with ISL1 and Kidney
 Umbilical Cord Antibodies  >2 publications with ISL1 and Umbilical Cord
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