eNOS Antibody – Mouse Monoclonal

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

eNOS: endothelial constitutive nitric oxide synthase. Synthesizes nitric oxide (NO) from arginine and oxygen, which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Induced in humans by caloric restriction. Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.

Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: caveola; cytoplasm; cytosol; Golgi membrane; nucleus; plasma membrane

Molecular Function: actin monomer binding; heme binding; nitric-oxide synthase activity; protein binding

Biological Process: arginine catabolic process; blood vessel remodeling; cell redox homeostasis; endothelial cell migration; mitochondrion organization and biogenesis; negative regulation of blood pressure; negative regulation of cell proliferation; negative regulation of muscle hyperplasia; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; positive regulation of angiogenesis; positive regulation of guanylate cyclase activity; positive regulation of vasodilation; regulation of blood vessel size; regulation of nitric-oxide synthase activity; regulation of systemic arterial blood pressure by endothelin; removal of superoxide radicals; smooth muscle hyperplasia

Disease: Alzheimer Disease; Hypertension, Essential; Preeclampsia/eclampsia 1; Stroke, Ischemic