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DKK3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475983

Entrez Summary: Dkk-3 (Dickkopf-3) is a member of the dickkopf family. It is a 350 amino acid secreted glycoprotein that is composed of an N-terminal signal peptide and two conserved cysteine-rich domains, which are separated by a 12 amino acid linker region.… More details

$525 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DKK3, Monoclonal Antibody
Full Product Name
Anti-DKK3 Mouse mAb
Product Gene Name
Product Synonym Gene Name
RIG; REIC
Product Synonym Names
RIG; REIC
Clonality
Monoclonal
Isotype
IgG1
Clone Number
4G7
Host
Mouse
Species Reactivity
Human, Monkey
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
38
OMIM
AF177396 mRNA
3D Structure
ModBase 3D Structure for Q9UBP4
Immunogen
Purified recombinant fragment of human DKK3 expressed in E Coli.
Applications Tested/Suitable for anti-DKK3 antibody
Western Blot (WB), Flow Cytometry (FC/FACS)

Western Blot (WB) of anti-DKK3 antibody

Western blot analysis using DKK3 mouse mAb against HEK293 (1), MCF-7 (2) and HL7702 (3) cell lysate.
Mouse Anti-DKK3 Monoclonal Antibody – Cat# MBS475983

Flow Cytometry (FC/FACS) of anti-DKK3 antibody

Flow cytometric analysis of MCF-7 cells using anti-DKK3 mAb (green) and negative control (purple).
Mouse Anti-DKK3 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS475983

Other Notes

Small volumes of anti-DKK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DKK3 purchase

MBS475983 is an antibody targeting DKK3. Also known as Anti-DKK3 Mouse mAb. Reactive in Human, Monkey. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DKK3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
dickkopf-related protein 3 isoform 1
NCBI Official Synonym Full Names
dickkopf WNT signaling pathway inhibitor 3
NCBI Official Symbol
DKK3
NCBI Official Synonym Symbols
RIG; REIC
UniProt Protein Name
Dickkopf-related protein 3
UniProt Gene Name
DKK3
UniProt Synonym Gene Names
REIC; Dickkopf-3; Dkk-3; hDkk-3
NCBI Protein Information
dickkopf-related protein 3

NCBI Summary for DKK3

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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UniProt Comments for DKK3

DKK3: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.3

Biological Process: adrenal gland development; anatomical structure morphogenesis; negative regulation of aldosterone biosynthetic process; negative regulation of transcription, DNA-dependent
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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