ARNTL Antibody – Mouse Monoclonal

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

BMAL1: aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Seven splice isoforms have been reported.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 11p15.3

Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus; transcription factor complex

Molecular Function: aryl hydrocarbon receptor binding; DNA binding; Hsp90 protein binding; protein binding; sequence-specific DNA binding

Biological Process: circadian regulation of gene expression; circadian rhythm; negative regulation of fat cell differentiation; negative regulation of TOR signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of circadian rhythm; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; regulation of cell cycle; regulation of hair cycle; regulation of insulin secretion; regulation of neurogenesis; regulation of transcription, DNA-dependent; response to redox state; spermatogenesis