Mouse Anti-GATA1 Monoclonal Antibody – Cat# MBS476016

Western blot analysis using GATA1 mouse mAb against K562 (1) cell lysate.

GATA1 Antibody – Mouse Monoclonal

Name: GATA1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS476016
Price: 525 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476016

Entrez Summary: erythroid specific transcription factor, GATA sequence binding protein (same as EryF1, NF-E1, EF-1, EF gamma-a, GF1), expressed in RBC, mast cell, megakaryocyte, hematopoietic progenitor cell, testis, associated with a special class of nuclear… More details

$525 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GATA1, Monoclonal Antibody

Full Product Name

Anti-GATA1 Mouse mAb

Product Gene Name

anti-GATA1 antibody

Product Synonym Gene Name

GF1; GF-1; NFE1; XLTT; ERYF1; GATA-1; GATA1

Product Synonym Names

GF1; GF-1; NFE1; XLTT; ERYF1; GATA-1; GATA1

Clonality

Monoclonal

Isotype

IgG1

Clone Number

4G1

Host

Mouse

Species Reactivity

Human

Form/Format

Ascitic fluid containing 0.03% sodium azide.

Molecular Weight

42.7

OMIM

X17254 mRNA

Immunogen

Purified recombinant fragment of human GATA1 expressed in E Coli.

Applications Tested/Suitable for anti-GATA1 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-GATA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GATA1 purchase

MBS476016 is an antibody targeting GATA1. Also known as Anti-GATA1 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GATA1. It may not necessarily be applicable to this product.

NCBI GI #

14602571

NCBI GeneID

2623

NCBI Accession #

AAH09797.1

UniProt Secondary Accession #

Q96GB8

UniProt Related Accession #

P15976

NCBI Official Full Name

GATA1 protein

NCBI Official Synonym Full Names

GATA binding protein 1

NCBI Official Symbol

GATA1

NCBI Official Synonym Symbols

GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1

UniProt Protein Name

Erythroid transcription factor

UniProt Synonym Protein Names

Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein

Protein Family

Erythroid transcription factor

UniProt Gene Name

GATA1

UniProt Synonym Gene Names

ERYF1; GF1; GATA-1; GF-1

NCBI Protein Information

erythroid transcription factor

NCBI Summary for GATA1

This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]

UniProt Comments for GATA1

GATA1: Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo. Interacts with EP300. Erythrocytes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: nucleoplasm; nucleus; transcription factor complex; transcriptional repressor complex

Molecular Function: chromatin DNA binding; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: basophil differentiation; blood coagulation; eosinophil differentiation; erythrocyte development; erythrocyte differentiation; gut development; heart development; male gonad development; megakaryocyte differentiation; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; organ morphogenesis; platelet formation; positive regulation of erythrocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; tissue development; transcription from RNA polymerase II promoter

Disease: Anemia, X-linked, With Or Without Neutropenia And/or Platelet Abnormalities; Down Syndrome; Thrombocytopenia With Beta-thalassemia, X-linked; Thrombocytopenia, X-linked, With Or Without Dyserythropoietic Anemia

Research Articles on GATA1

1. Data show that pyruvate kinase (PK) activity was decreased in the GATA1 hemizygous state and PKLR c.1284delA variant.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GATA1 antibody

Reference Product	PubMed Publications
TAL1 antibody	>92 publications with GATA1 and TAL1
ZFPM1 antibody	>65 publications with GATA1 and ZFPM1
MYB antibody	>35 publications with GATA1 and MYB
ZFPM2 antibody	>7 publications with GATA1 and ZFPM2
CREBBP antibody	>6 publications with GATA1 and CREBBP
HDAC1 antibody	>4 publications with GATA1 and HDAC1
HDAC5 antibody	>3 publications with GATA1 and HDAC5
HEY1 antibody	>2 publications with GATA1 and HEY1
HDAC4 antibody	>1 publications with GATA1 and HDAC4
HDAC3 antibody	>1 publications with GATA1 and HDAC3

Pathways associated with anti-GATA1 antibody

Products by Pathway	Pathway Diagram
C-MYB Transcription Factor Network Pathway antibodies	C-MYB Transcription Factor Network Pathway Diagram
Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies	Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
IL-3 Signaling Pathway antibodies	IL-3 Signaling Pathway Diagram
Notch-mediated HES/HEY Network Pathway antibodies	Notch-mediated HES/HEY Network Pathway Diagram
Signaling Events Mediated By HDAC Class I Pathway antibodies	Signaling Events Mediated By HDAC Class I Pathway Diagram
Signaling Events Mediated By HDAC Class II Pathway antibodies	Signaling Events Mediated By HDAC Class II Pathway Diagram

Diseases associated with anti-GATA1 antibody

Disease Name	Pubmed Publications
THROMBOCYTOPENIA, X-LINKED, WITH OR WITHOUT DYSERYTHROPOIETIC ANEMIA Antibodies	>651 publications with GATA1 and THROMBOCYTOPENIA, X-LINKED, WITH OR WITHOUT DYSERYTHROPOIETIC ANEMIA
Leukemia Antibodies	>368 publications with GATA1 and Leukemia
Neoplasms Antibodies	>312 publications with GATA1 and Neoplasms
Leukemia, Myeloid, Acute Antibodies	>230 publications with GATA1 and Leukemia, Myeloid, Acute
Bone Marrow Diseases Antibodies	>199 publications with GATA1 and Bone Marrow Diseases
Down Syndrome Antibodies	>157 publications with GATA1 and Down Syndrome
Anemia Antibodies	>127 publications with GATA1 and Anemia
Thrombocytopenia Antibodies	>63 publications with GATA1 and Thrombocytopenia
Chromosome Aberrations Antibodies	>44 publications with GATA1 and Chromosome Aberrations
Disease Models, Animal Antibodies	>36 publications with GATA1 and Disease Models, Animal

Organs/Tissues associated with anti-GATA1 antibody

Organ/Tissue Name	Pubmed Publications
Bone Marrow Antibodies	>171 publications with GATA1 and Bone Marrow
Lung Antibodies	>21 publications with GATA1 and Lung
Muscle Antibodies	>11 publications with GATA1 and Muscle
Connective Tissue Antibodies	>7 publications with GATA1 and Connective Tissue
Uncharacterized Tissue Antibodies	>1 publications with GATA1 and Uncharacterized Tissue