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KLHL21 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476033

Entrez Summary: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. More details

$525 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KLHL21, Monoclonal Antibody
Full Product Name
Anti-KLHL21 Mouse mAb
Product Gene Name
anti-KLHL21 antibody
Product Synonym Gene Name
KIAA0469; MGC99635; KLHL21
Product Synonym Names
KIAA0469; MGC99635; KLHL21
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2H4
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
66
OMIM
AB007938 mRNA
3D Structure
ModBase 3D Structure for Q9UJP4
Immunogen
Purified recombinant fragment of human KLHL21 expressed in E Coli.
Applications Tested/Suitable for anti-KLHL21 antibody
Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-KLHL21 antibody

Western blot analysis using KLHL21 mAb against human KLHL21 (AA
Mouse Anti-KLHL21 Monoclonal Antibody – Cat# MBS476033

Immunohistochemistry (IHC) of anti-KLHL21 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissues using KLHL21 mouse mAb with DAB staining.
Mouse Anti-KLHL21 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS476033

Other Notes

Small volumes of anti-KLHL21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLHL21 purchase

MBS476033 is an antibody targeting KLHL21. Also known as Anti-KLHL21 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for KLHL21. It may not necessarily be applicable to this product.

NCBI GI #
1024249331
NCBI GeneID
9903
NCBI Accession #
NP_001311238.1
UniProt Primary Accession #
Q9UJP4
UniProt Secondary Accession #
O75057; Q5SY26; Q5SY28; Q8N4I6; Q8NF10; B3KQP2
UniProt Related Accession #
Q9UJP4
GenBank Nucleotide #
NM_001324309.1
NCBI Official Full Name
kelch-like protein 21 isoform 2
NCBI Official Synonym Full Names
kelch like family member 21
NCBI Official Symbol
KLHL21
UniProt Protein Name
Kelch-like protein 21
Protein Family
Kelch-like protein
UniProt Gene Name
KLHL21
UniProt Synonym Gene Names
KIAA0469
NCBI Protein Information
kelch-like protein 21

UniProt Comments for KLHL21

KLHL21: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1p36.31

Cellular Component: centrosome; polar microtubule

Molecular Function: ubiquitin-protein ligase activity

Biological Process: protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of cytokinesis
Show more

Research Articles on KLHL21

1. KLHL21 localizes to midzone microtubules in anaphase & recruits aurora B & Cul3 to this region; results suggest that different Cul3 adaptors nonredundantly regulate aurora B during mitosis, possibly by ubiquitinating different pools of aurora B

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KLHL21 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
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