CCNB1 Antibody – Mouse Monoclonal

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008]

CCNB1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Complexes with cdc2 to form the maturation-promoting factor (MPF). Two alternatively spliced isoforms have been found, a constitutively expressed form and a cell cycle-regulated form that is expressed predominantly during G2/M phase.

Protein type: Activator; Cell cycle regulation

Chromosomal Location of Human Ortholog: 5q13.2

Cellular Component: centrosome; cytoplasm; cytosol; nucleoplasm; nucleus; spindle pole

Molecular Function: cyclin-dependent protein kinase activity; patched binding; protein binding; protein kinase binding

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G2/M transition of mitotic cell cycle; mitotic metaphase plate congression; mitotic nuclear envelope disassembly; mitotic spindle organization and biogenesis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle