STK11 Antibody – Mouse Monoclonal

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

LKB1: a S/T protein kinase of the CAMKL family. A tumor suppressor that helps control cell structure, polarity, apoptosis and energy homeostasis. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. A cytosolic protein complex comprised of LKB1, the pseudokinase STRAD, and the MO25 scaffold protein. Activates AMPK and several related protein kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. Mutation in the corresponding gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues.

Protein type: Autophagy; CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; LKB subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm; cytosol; membrane; mitochondrion; nucleoplasm; nucleus

Molecular Function: ATP binding; magnesium ion binding; p53 binding; protein binding; protein kinase activator activity; protein serine/threonine kinase activity

Biological Process: anoikis; cell cycle arrest; cell differentiation; establishment of cell polarity; glucose homeostasis; negative regulation of cell growth; negative regulation of cell proliferation; nervous system development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of autophagy; positive regulation of transforming growth factor beta receptor signaling pathway; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell growth; response to DNA damage stimulus; response to ionizing radiation; vasculature development

Disease: Pancreatic Cancer; Peutz-jeghers Syndrome; Testicular Germ Cell Tumor