SLC22A1 Antibody – Mouse Monoclonal

SLC22A1: Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 17 A1|17 8.63 cM

Cellular Component: basolateral plasma membrane; integral to plasma membrane

Molecular Function: acetylcholine transmembrane transporter activity; dopamine transmembrane transporter activity; monoamine transmembrane transporter activity; norepinephrine transmembrane transporter activity; organic cation transmembrane transporter activity; protein homodimerization activity; quaternary ammonium group transmembrane transporter activity; secondary active organic cation transmembrane transporter activity

Biological Process: cation transport; dopamine transport; epinephrine transport; establishment and/or maintenance of transmembrane electrochemical gradient; monoamine transport; multidrug transport; neurotransmitter transport; norepinephrine transport; organic cation transport; protein homooligomerization; quaternary ammonium group transport