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SUZ12 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476107

Entrez Summary: This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded… More details

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Product Overview

Online Datasheet in PDF
Product Name
SUZ12, Monoclonal Antibody
Full Product Name
Anti-SUZ12 Mouse mAb
Product Gene Name
anti-SUZ12 antibody
Product Synonym Gene Name
CHET9; JJAZ1; KIAA0160; SUZ12
Product Synonym Names
ChET 9 protein; CHET9; Chromatin precipitated E2F target 9 protein; JJAZ1; Joined to JAZF1 protein; KIAA0160; Polycomb protein SUZ12; Suppressor of zeste 12 homolog; Suppressor of zeste 12 protein homolog; SUZ12; SUZ12 polycomb repressive complex 2 subunit; SUZ12_HUMAN
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2B12-B4-C0
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
83kDa
OMIM
D63881 mRNA
3D Structure
ModBase 3D Structure for Q15022
Immunogen
Purified recombinant fragment of human SUZ12 expressed in E Coli.
Sequence Similarities
Contains 1 C2H2-type zinc finger.
Subunit Structure
Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with WDR77. Interacts with histone H1. Interacts with CDYL. Interacts with ARNTL/BMAL1.
Subcellular Location
Nucleus
Applications Tested/Suitable for anti-SUZ12 antibody
Western Blot (WB)

Western Blot (WB) of anti-SUZ12 antibody

Western blot detection of SUZ12 in Jurkat, A549 and MCF7 cell lysates using SUZ12 mouse mAb (1:1000 diluted).Predicted band size:83KDa.Observed band size:83KDa.
Mouse Anti-SUZ12 Monoclonal Antibody – Cat# MBS476107

Immunofluorescence (IF) of anti-SUZ12 antibody

Immunofluorescence analysis of U251 cells using SUZ12 mouse mAb (green). Red
Mouse Anti-SUZ12 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS476107

Immunofluorescence (IF) of anti-SUZ12 antibody

Immunofluorescence analysis of MCF-7 cells using SUZ12 mouse mAb (green). Red
Mouse Anti-SUZ12 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS476107

Other Notes

Small volumes of anti-SUZ12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SUZ12 purchase

MBS476107 is an antibody targeting SUZ12. Also known as Anti-SUZ12 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SUZ12. It may not necessarily be applicable to this product.

NCBI GI #
197333809
NCBI GeneID
23512
NCBI Accession #
NP_056170.2
UniProt Primary Accession #
Q15022
UniProt Secondary Accession #
Q96BD9
UniProt Related Accession #
Q15022
GenBank Nucleotide #
NM_015355.3
NCBI Official Full Name
polycomb protein SUZ12 isoform 1
NCBI Official Synonym Full Names
SUZ12 polycomb repressive complex 2 subunit
NCBI Official Symbol
SUZ12
NCBI Official Synonym Symbols
CHET9; JJAZ1
UniProt Protein Name
Polycomb protein SUZ12
UniProt Synonym Protein Names
Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog
Protein Family
Polycomb protein
UniProt Gene Name
SUZ12
UniProt Synonym Gene Names
CHET9; JJAZ1; KIAA0160; ChET 9 protein
NCBI Protein Information
polycomb protein SUZ12

NCBI Summary for SUZ12

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
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UniProt Comments for SUZ12

SUZ12: a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma.

Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: ESC/E(Z) complex; nucleolus; nucleoplasm; nucleus

Molecular Function: chromatin DNA binding; histone methyltransferase activity; methylated histone residue binding; protein binding

Biological Process: negative regulation of cell differentiation; negative regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent
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Research Articles on SUZ12

1. Mutations of SUZ12 and EED are reported to have tumor suppressive functions. (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SUZ12 antibody

 Reference Product  PubMed Publications
 EZH2 antibody  >102 publications with SUZ12 and EZH2
 EED antibody  >69 publications with SUZ12 and EED
 EZH1 antibody  >8 publications with SUZ12 and EZH1
 JARID2 antibody  >7 publications with SUZ12 and JARID2
 ASXL1 antibody  >5 publications with SUZ12 and ASXL1
 CTCF antibody  >5 publications with SUZ12 and CTCF
 RBBP7 antibody  >3 publications with SUZ12 and RBBP7
 RBBP4 antibody  >3 publications with SUZ12 and RBBP4
 AEBP2 antibody  >3 publications with SUZ12 and AEBP2

Diseases associated with anti-SUZ12 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >78 publications with SUZ12 and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >14 publications with SUZ12 and Cell Transformation, Neoplastic
 Endometrial Neoplasms Antibodies  >9 publications with SUZ12 and Endometrial Neoplasms
 Prostatic Diseases Antibodies  >8 publications with SUZ12 and Prostatic Diseases
 Lung Neoplasms Antibodies  >8 publications with SUZ12 and Lung Neoplasms
 Adenocarcinoma Antibodies  >6 publications with SUZ12 and Adenocarcinoma
 Congenital Abnormalities Antibodies  >6 publications with SUZ12 and Congenital Abnormalities
 Liver Diseases Antibodies  >5 publications with SUZ12 and Liver Diseases
 Liver Neoplasms Antibodies  >4 publications with SUZ12 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with SUZ12 and Carcinoma, Hepatocellular
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