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MAP2K6 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476130

Entrez Summary: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MAP2K6, Monoclonal Antibody
Full Product Name
Anti-MAP2K6 Mouse mAb
Product Gene Name
Product Synonym Gene Name
MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; MAP2K6
Product Synonym Names
MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; MAP2K6
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3H12C8
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
38
OMIM
U39657 mRNA
Immunogen
Purified recombinant fragment of human MAP2K6 expressed in E Coli.
Applications Tested/Suitable for anti-MAP2K6 antibody
Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

Western Blot (WB) of anti-MAP2K6 antibody

Western blot analysis using MAP2K6 mouse mAb against HepG2 (1), MCF-7 (2) and NIH/3T3 (3) cell lysate.
Mouse Anti-MAP2K6 Monoclonal Antibody – Cat# MBS476130

Immunofluorescence (IF) of anti-MAP2K6 antibody

Immunofluorescence analysis of Hela cells using MAP2K6 mouse mAb (green). Blue
Mouse Anti-MAP2K6 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS476130

Flow Cytometry (FC/FACS) of anti-MAP2K6 antibody

Flow cytometric analysis of Hela cells using MAP2K6 mouse mAb (green) and negative control (purple).
Mouse Anti-MAP2K6 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS476130

Other Notes

Small volumes of anti-MAP2K6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAP2K6 purchase

MBS476130 is an antibody targeting MAP2K6. Also known as Anti-MAP2K6 Mouse mAb. Reactive in Human, Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MAP2K6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Related Accession #
NCBI Official Full Name
MAP2K6, partial
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase 6
NCBI Official Symbol
MAP2K6
NCBI Official Synonym Symbols
MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3
UniProt Protein Name
Dual specificity mitogen-activated protein kinase kinase 6
UniProt Synonym Protein Names
MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3
UniProt Gene Name
MAP2K6
UniProt Synonym Gene Names
MEK6; MKK6; PRKMK6; SKK3; MAP kinase kinase 6; MAPKK 6; MEK 6; SAPK kinase 3; SAPKK-3; SAPKK3
NCBI Protein Information
dual specificity mitogen-activated protein kinase kinase 6

NCBI Summary for MAP2K6

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
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UniProt Comments for MAP2K6

MKK6: a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported.

Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: MAP kinase kinase activity; protein binding; protein kinase binding; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of MAPK activity; cell cycle arrest; DNA damage induced protein phosphorylation; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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