GNB2 Antibody – Rabbit Monoclonal

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]

G-beta 2: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the WD repeat G protein beta family.

Protein type: G protein, heterotrimeric beta; G protein; G protein, heterotrimeric

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: extracellular space; focal adhesion; lysosomal membrane; membrane; myelin sheath; perinuclear region of cytoplasm; plasma membrane; protein complex; vesicle

Molecular Function: calcium channel regulator activity; GTPase activity; GTPase binding; protein binding; protein complex binding; signal transducer activity

Biological Process: energy reserve metabolic process; G-protein coupled receptor protein signaling pathway; synaptic transmission