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KCNQ1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476238

Entrez Summary: This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are… More details

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Product Overview

Online Datasheet in PDF
Product Name
KCNQ1, Monoclonal Antibody
Full Product Name
Anti-KCNQ1 Mouse mAb
Product Gene Name
anti-KCNQ1 antibody
Product Synonym Gene Name
LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
Product Synonym Names
ATFB1; ATFB3; FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; Jervell and Lange-Nielsen syndrome 1; JLNS1; KCNA8; KCNA9; KCNQ1; KCNQ1_HUMAN; kidney and cardiac voltage dependend K+ channel; KQT-like 1; Kv1.9; Kv7.1; KVLQT1; long (electrocardiographic) QT syndrome, Ward-Romano syndrome 1; LQT; LQT1; Potassium channel, voltage-gated, shaker-relatd subfamily, member 9; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; RWS; slow delayed rectifier channel subunit; SQT2; Voltage-gated potassium channel subunit Kv7.1; WRS
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
7E1-F6-F10
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
95kDa
OMIM
AF000571 mRNA
3D Structure
ModBase 3D Structure for P51787
Immunogen
Purified recombinant fragment of human KCNQ1 expressed in E Coli.
Sequence Similarities
Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.
Subunit Structure
Tetramer (PubMed:18165683, PubMed:19693805). Heterotetramer with KCNE1; targets to the membrane raft (PubMed:25037568, PubMed:19693805, PubMed:20533308). Interacts (via C-terminus) with CALM; forms a heterotetramer in a calcium-independent manner (PubMed:18165683). Interacts with AKAP9; targets protein kinase A (PKA) catalytic and regulatory subunits and protein phosphatase 1 (PP1) to the KCNQ1-KCNE1 complex, allowing PKA-mediated phosphorylation and increase of delayed rectifier potassium channel activity (PubMed:11799244, PubMed:25037568). Interacts with KCNE2; forms a heterooligomer complex that targets to the membrane raft and leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505, PubMed:20533308). Interacts with AP2M1; mediates estrogen-induced internalization via clathrin-coated vesicles (PubMed:23529131). Interacts with NEDD4L; promotes internalization and decreases I (Ks) currents (PubMed:23529131, PubMed:22024150). Interacts with USP2; counteracts the NEDD4L-specific down-regulation of I (Ks) and restore plasma membrane localization (PubMed:22024150). Heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Interacts with KCNE3; alters membrane raft localization (PubMed:20533308). Interacts with KCNE4; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity (PubMed:19687231, PubMed:20533308). Interacts with KCNE5; impairs KCNQ1 localization in lipid rafts and only conducts current upon strong and continued depolarization (PubMed:20533308, PubMed:12324418).
Subcellular Location
Basolateral cell membrane
Applications Tested/Suitable for anti-KCNQ1 antibody
Western Blot (WB)

Western Blot (WB) of anti-KCNQ1 antibody

Western blot detection of KCNQ1 in C6, Jurkat, K562 and 3T3 cell lysates using KCNQ1 mouse mAb (1:3000 diluted).Predicted band size:95KDa.Observed band size:95KDa.
Mouse Anti-KCNQ1 Monoclonal Antibody – Cat# MBS476238

Western Blot (WB) of anti-KCNQ1 antibody

Western blot analysis using KCNQ1 mouse mAb against MCF-7 (1) and A431 (2) cell lysate.
Mouse Anti-KCNQ1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476238

Flow Cytometry (FC/FACS) of anti-KCNQ1 antibody

Flow cytometric analysis of MCF-7 cells using KCNQ1 mouse mAb (green) and negative control (red).
Mouse Anti-KCNQ1 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS476238

Other Notes

Small volumes of anti-KCNQ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNQ1 purchase

MBS476238 is an antibody targeting KCNQ1. Also known as Anti-KCNQ1 Mouse mAb. Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNQ1. It may not necessarily be applicable to this product.

NCBI GI #
32479527
NCBI GeneID
3784
NCBI Accession #
NP_000209.2
UniProt Primary Accession #
P51787
UniProt Secondary Accession #
O00347; O60607; O94787; Q14D14; Q7Z6G9; Q92960; Q9UMN8; Q9UMN9
UniProt Related Accession #
P51787
GenBank Nucleotide #
NM_000218.2
NCBI Official Full Name
potassium voltage-gated channel subfamily KQT member 1 isoform 1
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily Q member 1
NCBI Official Symbol
KCNQ1
NCBI Official Synonym Symbols
LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
UniProt Protein Name
Potassium voltage-gated channel subfamily KQT member 1
UniProt Synonym Protein Names
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNQ1
NCBI Protein Information
potassium voltage-gated channel subfamily KQT member 1

NCBI Summary for KCNQ1

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
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UniProt Comments for KCNQ1

Kv7.1: a voltage-gated potassium channel protein required for the repolarization phase of the cardiac action potential. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries. Three alternatively spliced isoforms have been described.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p15.5-p15.4

Cellular Component: basolateral plasma membrane; cytoplasm; early endosome; endoplasmic reticulum; late endosome; lipid raft; lysosome; plasma membrane; voltage-gated potassium channel complex

Molecular Function: calmodulin binding; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein phosphatase 1 binding; voltage-gated potassium channel activity

Biological Process: cardiac muscle contraction; inner ear development; intestinal absorption; positive regulation of heart rate; regulation of heart contraction; sensory perception of sound

Disease: Atrial Fibrillation, Familial, 3; Beckwith-wiedemann Syndrome; Jervell And Lange-nielsen Syndrome 1; Long Qt Syndrome 1; Short Qt Syndrome 2
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Research Articles on KCNQ1

1. 176 cases of drowning were screened for mutations in the exons 3, 5, 6, 7, and 8 of the KCNQ1; no variation to the published sequence could be found in the exonic DNA in any of the cases clearly disproving an involvement of these mutation clusters in cases of drowning

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNQ1 antibody

 Reference Product  PubMed Publications
 KCNE1 antibody  >447 publications with KCNQ1 and KCNE1
 KCNH2 antibody  >168 publications with KCNQ1 and KCNH2
 KCNE2 antibody  >137 publications with KCNQ1 and KCNE2
 KCNQ2 antibody  >67 publications with KCNQ1 and KCNQ2
 KCNE3 antibody  >65 publications with KCNQ1 and KCNE3
 KCNH6 antibody  >58 publications with KCNQ1 and KCNH6
 AKAP9 antibody  >11 publications with KCNQ1 and AKAP9
 KCNA5 antibody  >10 publications with KCNQ1 and KCNA5
 KCNA4 antibody  >3 publications with KCNQ1 and KCNA4

Pathways associated with anti-KCNQ1 antibody

 Products by Pathway  Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram

Diseases associated with anti-KCNQ1 antibody

 Disease Name  Pubmed Publications
 Arrhythmias, Cardiac Antibodies  >588 publications with KCNQ1 and Arrhythmias, Cardiac
 Heart Diseases Antibodies  >576 publications with KCNQ1 and Heart Diseases
 Long QT Syndrome Antibodies  >553 publications with KCNQ1 and Long QT Syndrome
 Death, Sudden, Cardiac Antibodies  >230 publications with KCNQ1 and Death, Sudden, Cardiac
 Syncope Antibodies  >112 publications with KCNQ1 and Syncope
 Heart Arrest Antibodies  >85 publications with KCNQ1 and Heart Arrest
 Tachycardia Antibodies  >83 publications with KCNQ1 and Tachycardia
 Romano-Ward Syndrome Antibodies  >80 publications with KCNQ1 and Romano-Ward Syndrome
 Tachycardia, Ventricular Antibodies  >79 publications with KCNQ1 and Tachycardia, Ventricular
 Diabetes Mellitus, Type 2 Antibodies  >76 publications with KCNQ1 and Diabetes Mellitus, Type 2

Organs/Tissues associated with anti-KCNQ1 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >466 publications with KCNQ1 and Heart
 Blood Antibodies  >95 publications with KCNQ1 and Blood
 Kidney Antibodies  >73 publications with KCNQ1 and Kidney
 Brain Antibodies  >44 publications with KCNQ1 and Brain
 Intestine Antibodies  >43 publications with KCNQ1 and Intestine
 Stomach Antibodies  >41 publications with KCNQ1 and Stomach
 Ovary Antibodies  >41 publications with KCNQ1 and Ovary
 Lung Antibodies  >34 publications with KCNQ1 and Lung
 Pancreas Antibodies  >32 publications with KCNQ1 and Pancreas
 Liver Antibodies  >27 publications with KCNQ1 and Liver
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