CEBPA Antibody – Mouse Monoclonal

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]

C/EBP-alpha: a bZIP transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 19q13.11

Cellular Component: nucleus

Molecular Function: DNA binding; kinase binding; protein binding; protein homodimerization activity; transcription coactivator activity; transcription factor activity; transcription factor binding

Biological Process: fat cell differentiation; generation of precursor metabolites and energy; glucose homeostasis; granulocyte differentiation; lipid homeostasis; liver development; lung development; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription, DNA-dependent; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; transcription from RNA polymerase II promoter; transcription, DNA-dependent

Disease: Leukemia, Acute Myeloid