PRKACG Antibody – Mouse Monoclonal

Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]

PKACG: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript. Activated by cAMP. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

Protein type: AGC group; EC 2.7.11.11; Kinase, protein; PKA family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 9q21.11

Cellular Component: cytosol; nucleoplasm

Molecular Function: cAMP-dependent protein kinase activity; protein serine/threonine kinase activity

Biological Process: activation of protein kinase A; blood coagulation; lipoprotein metabolic process; male gonad development; renal water homeostasis; spermatogenesis; stimulatory C-type lectin receptor signaling pathway

Disease: Mental Retardation, Autosomal Dominant 31