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VAV1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476327

Entrez Summary: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell… More details

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Product Overview

Online Datasheet in PDF
Product Name
Vav1, Monoclonal Antibody
Full Product Name
Anti-Vav1 Mouse mAb
Product Gene Name
anti-Vav1 antibody
Product Synonym Gene Name
VAV
Product Synonym Names
Oncogene vav; p95Vav; Proto-oncogene vav; Protooncogene vav; VAV 1; VAV 1 oncogene; VAV; Vav proto oncogene; VAV_HUMAN; VAV1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
5E7-F8-B9
Host
Mouse
Species Reactivity
Human
Form/Format
Purified antibody in PBS with 0.05% sodium azide.
Molecular Weight
95kDa
3D Structure
ModBase 3D Structure for P15498
Immunogen
Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E Coli.
Sequence Similarities
Contains 2 SH3 domains.
Subunit Structure
Interacts with SHB (PubMed:12084069). Interacts with APS, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK (PubMed:12393632, PubMed:12400014, PubMed:15558030). Interacts with SIAH2; without leading to its degradation (PubMed:10207103). Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion (PubMed:9697839). Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity (PubMed:9399639). May interact with CCPG1. Interacts with CLNK. Interacts with THEMIS2 (By similarity). Interacts with NEK3 and this interaction is prolactin-dependent (PubMed:15618286). Interacts with ITK (PubMed:15661896). Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2 (PubMed:19207108). Interacts (via SH2 domain) with SYK (PubMed:8986718). Interacts with ANKRD54. Interacts with CD6 (By similarity).
Applications Tested/Suitable for anti-Vav1 antibody
Western Blot (WB)

Western Blot (WB) of anti-Vav1 antibody

Western blot detection of Vav1 in Jurkat cell lysates using Vav1 mouse mAb (1:3000 diluted).Predicted band size:98KDa.Observed band size:95KDa.
Mouse Anti-VAV1 Monoclonal Antibody – Cat# MBS476327

Western Blot (WB) of anti-Vav1 antibody

Western blot analysis using VAV1 mAb against HEK293 (1) and VAV1 (AA
Mouse Anti-VAV1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476327

Western Blot (WB) of anti-Vav1 antibody

Western blot analysis using VAV1 mouse mAb against Jurkat (1) cell lysate.
Mouse Anti-VAV1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476327

Flow Cytometry (FC/FACS) of anti-Vav1 antibody

Flow cytometric analysis of HeLa cells using VAV1 mouse mAb (green) and negative control (red).
Mouse Anti-VAV1 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS476327

Other Notes

Small volumes of anti-Vav1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Vav1 purchase

MBS476327 is an antibody targeting Vav1. Also known as Anti-Vav1 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Vav1. It may not necessarily be applicable to this product.

NCBI GI #
384551649
NCBI GeneID
7409
NCBI Accession #
NP_001245136.1
UniProt Primary Accession #
P15498
UniProt Secondary Accession #
Q15860; B4DVK9; M0QXX6
UniProt Related Accession #
P15498
GenBank Nucleotide #
NM_001258207.1
NCBI Official Full Name
proto-oncogene vav isoform 3
NCBI Official Synonym Full Names
vav guanine nucleotide exchange factor 1
NCBI Official Symbol
VAV1
NCBI Official Synonym Symbols
VAV
UniProt Protein Name
Proto-oncogene vav
Protein Family
Proto-oncogene
UniProt Gene Name
VAV1
UniProt Synonym Gene Names
VAV
NCBI Protein Information
proto-oncogene vav

NCBI Summary for Vav1

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
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UniProt Comments for Vav1

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Research Articles on Vav1

1. Our results suggest the existence of a Vav1/PU.1/miR-142-3p network that supports all-trans retinoic acid -induced differentiation in acute promyelocytic leukemia -derived cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Vav1 antibody

 Reference Product  PubMed Publications
 RAC1 antibody  >104 publications with Vav1 and RAC1
 SYK antibody  >61 publications with Vav1 and SYK
 CDC42 antibody  >58 publications with Vav1 and CDC42
 ZAP70 antibody  >48 publications with Vav1 and ZAP70
 GRB2 antibody  >46 publications with Vav1 and GRB2
 CBL antibody  >39 publications with Vav1 and CBL
 CD19 antibody  >13 publications with Vav1 and CD19
 SOCS1 antibody  >2 publications with Vav1 and SOCS1
 BLNK antibody  >2 publications with Vav1 and BLNK
 LCP2 antibody  >1 publications with Vav1 and LCP2

Pathways associated with anti-Vav1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram

Diseases associated with anti-Vav1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >24 publications with Vav1 and Inflammation
 Carcinoma Antibodies  >16 publications with Vav1 and Carcinoma
 Neoplasms, Experimental Antibodies  >15 publications with Vav1 and Neoplasms, Experimental
 Necrosis Antibodies  >14 publications with Vav1 and Necrosis
 Cardiovascular Diseases Antibodies  >14 publications with Vav1 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >10 publications with Vav1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >7 publications with Vav1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >6 publications with Vav1 and Breast Neoplasms
 Atherosclerosis Antibodies  >6 publications with Vav1 and Atherosclerosis
 Congenital Abnormalities Antibodies  >4 publications with Vav1 and Congenital Abnormalities

Organs/Tissues associated with anti-Vav1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >391 publications with Vav1 and Blood
 Bone Antibodies  >45 publications with Vav1 and Bone
 Bone Marrow Antibodies  >40 publications with Vav1 and Bone Marrow
 Thymus Antibodies  >24 publications with Vav1 and Thymus
 Spleen Antibodies  >21 publications with Vav1 and Spleen
 Lung Antibodies  >16 publications with Vav1 and Lung
 Lymph Node Antibodies  >14 publications with Vav1 and Lymph Node
 Lymph Antibodies  >10 publications with Vav1 and Lymph
 Brain Antibodies  >7 publications with Vav1 and Brain
 Ovary Antibodies  >3 publications with Vav1 and Ovary
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