ITGB4 Antibody – Mouse Monoclonal

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ITGB4: integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: cell junction; cell surface; hemidesmosome; leading edge; nucleus; plasma membrane; receptor complex

Molecular Function: G-protein-coupled receptor binding; insulin-like growth factor I binding; protein binding

Biological Process: autophagy; cell motility involved in cell locomotion; cell-matrix adhesion; extracellular matrix organization and biogenesis; gut development; hemidesmosome assembly; mesodermal cell differentiation; response to wounding; skin development

Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia; Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa, Junctional, Non-herlitz Type