Rabbit Anti-PTK6 Monoclonal Antibody – Cat# MBS4764017

Brk/PTK6 (PTK6) Antibody – Rabbit Monoclonal

Name: PTK6 Antibody; Monoclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS4764017
Price: 525 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4764017

Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on… More details

$525 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Brk/PTK6, Monoclonal Antibody

Full Product Name

Brk/PTK6 Rabbit mAb

Product Gene Name

anti-PTK6 antibody

Product Synonym Gene Name

Brk/PTK6

Product Synonym Names

PTK6; BRK; Protein-tyrosine kinase 6; Breast tumor kinase; Tyrosine-protein kinase BRK

Clonality

Monoclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid; Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.283.

Purity/Purification

Affinity Purified

Preparation and Storage

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycles.

Molecular Weight

51,834 Da

Chromosome Location

Chromosome: 20; NC_000020.10 (62159766..62168723, complement). Location: 20q13.3

OMIM

602004

3D Structure

ModBase 3D Structure for Q13882

Immunogen

Recombinant protein of human Brk

Conjugation

Unconjugated

Modification

Unmodified

Research Area

Signal Transduction

Product Categories/Family for anti-PTK6 antibody

Home; Products; Featured Collections; Recombinant Rabbit Monoclonal Antibodies; Primary antibody

Applications Tested/Suitable for anti-PTK6 antibody

Immunohistochemistry-Paraffin (IHC-P)

Application Notes for anti-PTK6 antibody

IHC: 1/100-1/200

Other Notes

Small volumes of anti-PTK6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTK6 purchase

MBS4764017 is an antibody targeting PTK6. Also known as Brk/PTK6 Rabbit mAb. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTK6. It may not necessarily be applicable to this product.

NCBI GI #

373432692

NCBI GeneID

5753

NCBI Accession #

NP_001243287.1

UniProt Primary Accession #

Q13882

UniProt Secondary Accession #

Q58F01; B2RCR3; B4DW46

UniProt Related Accession #

Q13882

GenBank Nucleotide #

NM_001256358.1

NCBI Official Full Name

protein-tyrosine kinase 6 isoform 2

NCBI Official Synonym Full Names

protein tyrosine kinase 6

NCBI Official Symbol

PTK6

NCBI Official Synonym Symbols

BRK

UniProt Protein Name

Protein-tyrosine kinase 6

UniProt Synonym Protein Names

Breast tumor kinase; Tyrosine-protein kinase BRK

Protein Family

Protein-tyrosine kinase

UniProt Gene Name

PTK6

UniProt Synonym Gene Names

BRK

UniProt Entry Name

PTK6_HUMAN

NCBI Protein Information

protein-tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kinase BRK; PTK6 protein tyrosine kinase 6

NCBI Summary for PTK6

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

UniProt Comments for PTK6

Brk: a tyrosine kinase of the Src family. May function as an intracellular signal transducer in epithelial tissues. Very high level expression in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. Selectively expressed in breast tumors and cell lines, and perhaps in colon and prostate cancers. Also found in melanocytes. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Overexpression in mammary cells leads to EGF sensitization and results in a partially transformed phenotype. Enhances anchorage-independent growth and responsiveness to EGF. RNAi reduces proliferation in breast cancer cells. Kinase-inactive mutant indicates tumor function may be independent of catalytic function.

Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; TK group; Src family

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: nucleoplasm; ruffle; extrinsic to internal side of plasma membrane; cytoplasm; nucleus

Molecular Function: identical protein binding; protein binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: cell migration; protein amino acid autophosphorylation; innate immune response; tyrosine phosphorylation of Stat3 protein; actin cytoskeleton organization and biogenesis; tyrosine phosphorylation of Stat5 protein; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation; negative regulation of growth

Research Articles on PTK6

1. These results provide evidence for a novel mechanism demonstrating the oncogenic potential of PTK6 through degradation of c-Cbl, which is an E3 ligase important in down-regulation of oncoproteins.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTK6 antibody

Reference Product	PubMed Publications
KHDRBS1 antibody	>8 publications with PTK6 and KHDRBS1
EGFR antibody	>6 publications with PTK6 and EGFR
ERBB3 antibody	>1 publications with PTK6 and ERBB3

Pathways associated with anti-PTK6 antibody

Products by Pathway	Pathway Diagram
EGFR1 Signaling Pathway antibodies	EGFR1 Signaling Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram

Diseases associated with anti-PTK6 antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>38 publications with PTK6 and Breast Neoplasms
Carcinoma Antibodies	>22 publications with PTK6 and Carcinoma
Neoplasms, Experimental Antibodies	>7 publications with PTK6 and Neoplasms, Experimental
Gastrointestinal Diseases Antibodies	>6 publications with PTK6 and Gastrointestinal Diseases
Neoplasm Metastasis Antibodies	>5 publications with PTK6 and Neoplasm Metastasis
Ovarian Neoplasms Antibodies	>3 publications with PTK6 and Ovarian Neoplasms
Cell Transformation, Neoplastic Antibodies	>3 publications with PTK6 and Cell Transformation, Neoplastic
Lung Neoplasms Antibodies	>1 publications with PTK6 and Lung Neoplasms
Esophageal Neoplasms Antibodies	>1 publications with PTK6 and Esophageal Neoplasms

Organs/Tissues associated with anti-PTK6 antibody

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>10 publications with PTK6 and Intestine
Prostate Antibodies	>9 publications with PTK6 and Prostate
Skin Antibodies	>8 publications with PTK6 and Skin
Mammary Gland Antibodies	>8 publications with PTK6 and Mammary Gland
Kidney Antibodies	>2 publications with PTK6 and Kidney
Blood Antibodies	>2 publications with PTK6 and Blood
Lymph Node Antibodies	>2 publications with PTK6 and Lymph Node
Lung Antibodies	>2 publications with PTK6 and Lung
Brain Antibodies	>1 publications with PTK6 and Brain
Mouth Antibodies	>1 publications with PTK6 and Mouth