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PLAUR Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4764265

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized… More details

$525 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
uPAR (PLAUR), Monoclonal Antibody
Full Product Name
uPAR Rabbit mAb
Product Gene Name
anti-PLAUR antibody
Product Synonym Gene Name
uPAR
Product Synonym Names
U-PAR; Monocyte activation antigen Mo3; CD87
Clonality
Monoclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid; Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.166.
Purity/Purification
Affinity Purified
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycles.
Molecular Weight
36,978 Da
OMIM
173391
3D Structure
ModBase 3D Structure for Q03405
Immunogen
Recombinant protein of human uPAR
Conjugation
Unconjugated
Modification
Unmodified
Research Area
Cardiovascular

Product Categories/Family for anti-PLAUR antibody

Home; Products; Featured Collections; Recombinant Rabbit Monoclonal Antibodies; Primary antibody
Applications Tested/Suitable for anti-PLAUR antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes for anti-PLAUR antibody
IHC: 1/100-1/200

Other Notes

Small volumes of anti-PLAUR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLAUR purchase

MBS4764265 is an antibody targeting PLAUR. Also known as uPAR Rabbit mAb. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PLAUR. It may not necessarily be applicable to this product.

NCBI GI #
4505865
NCBI GeneID
5329
NCBI Accession #
NP_002650.1
UniProt Primary Accession #
Q03405
UniProt Secondary Accession #
Q12876; Q15845; Q16887; Q6IB52; Q9BWT0; Q9NYC8; Q9UD69; Q9UEA6; Q9UM92; Q9UMV0; A8K409
UniProt Related Accession #
Q03405
GenBank Nucleotide #
NM_002659.3
NCBI Official Full Name
urokinase plasminogen activator surface receptor isoform 1
NCBI Official Synonym Full Names
plasminogen activator, urokinase receptor
NCBI Official Symbol
PLAUR
NCBI Official Synonym Symbols
CD87; UPAR; URKR; U-PAR
UniProt Protein Name
Urokinase plasminogen activator surface receptor
UniProt Synonym Protein Names
Monocyte activation antigen Mo3
Protein Family
Urokinase plasminogen activator surface receptor
UniProt Gene Name
PLAUR
UniProt Synonym Gene Names
MO3; UPAR; U-PAR; uPAR
UniProt Entry Name
UPAR_HUMAN
NCBI Protein Information
urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2; urokinase-type plasminogen activator (uPA) receptor

UniProt Comments for PLAUR

uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, GPI anchor; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: endoplasmic reticulum membrane; extrinsic to membrane; focal adhesion; integral to plasma membrane; endoplasmic reticulum lumen; integral to membrane; plasma membrane

Molecular Function: protein domain specific binding; protein binding; U-plasminogen activator receptor activity; enzyme binding; receptor activity; receptor binding

Biological Process: fibrinolysis; cellular protein metabolic process; attachment of GPI anchor to protein; regulation of proteolysis; C-terminal protein lipidation; chemotaxis; post-translational protein modification; cell motility; blood coagulation; signal transduction
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Research Articles on PLAUR

1. HIV-1 infected lymphoid organs upregulate expression and release of the cleaved form of uPAR that modulates chemotaxis and virus expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PLAUR antibody

 Products by Pathway  Pathway Diagram
 Arf6 Downstream Pathway antibodies  Arf6 Downstream Pathway Diagram
 Attachment Of GPI Anchor To UPAR Pathway antibodies  Attachment Of GPI Anchor To UPAR Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway antibodies  Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway Diagram

Diseases associated with anti-PLAUR antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >816 publications with PLAUR and Neoplasms
 Carcinoma Antibodies  >313 publications with PLAUR and Carcinoma
 Neoplasm Invasiveness Antibodies  >261 publications with PLAUR and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >239 publications with PLAUR and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >164 publications with PLAUR and Breast Neoplasms
 Inflammation Antibodies  >111 publications with PLAUR and Inflammation
 Lung Diseases Antibodies  >90 publications with PLAUR and Lung Diseases
 Nervous System Diseases Antibodies  >83 publications with PLAUR and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >83 publications with PLAUR and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >76 publications with PLAUR and Lung Neoplasms

Organs/Tissues associated with anti-PLAUR antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >504 publications with PLAUR and Blood
 Vascular Antibodies  >301 publications with PLAUR and Vascular
 Lung Antibodies  >147 publications with PLAUR and Lung
 Muscle Antibodies  >98 publications with PLAUR and Muscle
 Brain Antibodies  >86 publications with PLAUR and Brain
 Liver Antibodies  >83 publications with PLAUR and Liver
 Embryonic Tissue Antibodies  >80 publications with PLAUR and Embryonic Tissue
 Bone Antibodies  >80 publications with PLAUR and Bone
 Kidney Antibodies  >75 publications with PLAUR and Kidney
 Prostate Antibodies  >65 publications with PLAUR and Prostate
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