SLC27A2 Antibody – Mouse Monoclonal

The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

SLC27A2: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.2.1.3; Ligase; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to peroxisomal membrane; peroxisomal membrane

Molecular Function: enzyme binding; long-chain-fatty-acid-CoA ligase activity; phytanate-CoA ligase activity; receptor binding; very-long-chain-fatty-acid-CoA ligase activity

Biological Process: bile acid biosynthetic process; fatty acid alpha-oxidation; fatty acid beta-oxidation; long-chain fatty acid metabolic process