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ITGAM Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476477

Entrez Summary: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
ITGAM, Monoclonal Antibody
Full Product Name
Anti-ITGAM Mouse mAb
Product Gene Name
Product Synonym Gene Name
CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
Product Synonym Names
CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3A10H5
Host
Mouse
Species Reactivity
Human
Form/Format
Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
Molecular Weight
127.1
OMIM
J03925 mRNA
3D Structure
ModBase 3D Structure for P11215
Immunogen
Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E Coli.
Applications Tested/Suitable for anti-ITGAM antibody
Western Blot (WB), Immunocytochemistry (ICC)

Western Blot (WB) of anti-ITGAM antibody

Western blot analysis using ITGAM mAb against human ITGAM recombinant protein. (Expected MW is 37.5 kDa)
Mouse Anti-ITGAM Monoclonal Antibody – Cat# MBS476477

Western Blot (WB) of anti-ITGAM antibody

Western blot analysis using ITGAM mAb against HEK293 (1) and ITGAM (AA
Mouse Anti-ITGAM Monoclonal Antibody, Western Blot (WB) – Cat# MBS476477

Immunofluorescence (IF) of anti-ITGAM antibody

Immunofluorescence analysis of Hela cells using ITGAM mouse mAb (green). Blue
Mouse Anti-ITGAM Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS476477

Other Notes

Small volumes of anti-ITGAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITGAM purchase

MBS476477 is an antibody targeting ITGAM. Also known as Anti-ITGAM Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ITGAM. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
integrin alpha-M isoform 1
NCBI Official Synonym Full Names
integrin subunit alpha M
NCBI Official Symbol
ITGAM
NCBI Official Synonym Symbols
CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
UniProt Protein Name
Integrin alpha-M
UniProt Synonym Protein Names
CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD_antigen: CD11b
Protein Family
UniProt Gene Name
ITGAM
UniProt Synonym Gene Names
CD11B; CR3A
NCBI Protein Information
integrin alpha-M

NCBI Summary for ITGAM

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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UniProt Comments for ITGAM

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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