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GAB2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476545

Entrez Summary: This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various… More details

$525 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GAB2, Monoclonal Antibody
Full Product Name
Anti-GAB2 Mouse mAb
Product Gene Name
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
1F6D9
Host
Mouse
Species Reactivity
Human
Form/Format
Purified antibody in PBS with 0.05% sodium azide.
Molecular Weight
74.5
OMIM
AB018413 mRNA
3D Structure
ModBase 3D Structure for Q9UQC2
Immunogen
Purified recombinant fragment of human GAB2 (AA: 332-476) expressed in E Coli.
Applications Tested/Suitable for anti-GAB2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

Western Blot (WB) of anti-GAB2 antibody

Western blot analysis using GAB2 mAb against human GAB2 (AA
Mouse Anti-GAB2 Monoclonal Antibody – Cat# MBS476545

Western Blot (WB) of anti-GAB2 antibody

Western blot analysis using GAB2 mAb against HEK293 (1) and GAB2 (AA
Mouse Anti-GAB2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476545

Immunofluorescence (IF) of anti-GAB2 antibody

Immunofluorescence analysis of Hela cells using GAB2 mouse mAb (green). Blue
Mouse Anti-GAB2 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS476545

Flow Cytometry (FC/FACS) of anti-GAB2 antibody

Flow cytometric analysis of Hela cells using GAB2 mouse mAb (green) and negative control (red).
Mouse Anti-GAB2 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS476545

Immunohistochemistry (IHC) of anti-GAB2 antibody

Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using GAB2 mouse mAb with DAB staining.
Mouse Anti-GAB2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS476545

Immunohistochemistry (IHC) of anti-GAB2 antibody

Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using GAB2 mouse mAb with DAB staining.
Mouse Anti-GAB2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS476545

Other Notes

Small volumes of anti-GAB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GAB2 purchase

MBS476545 is an antibody targeting GAB2. Also known as Anti-GAB2 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GAB2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
GRB2-associated-binding protein 2 isoform a
NCBI Official Synonym Full Names
GRB2 associated binding protein 2
NCBI Official Symbol
GAB2
UniProt Protein Name
GRB2-associated-binding protein 2
UniProt Synonym Protein Names
GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100
UniProt Gene Name
GAB2
UniProt Synonym Gene Names
KIAA0571
NCBI Protein Information
GRB2-associated-binding protein 2

NCBI Summary for GAB2

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
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UniProt Comments for GAB2

GAB2: an adaptor protein of the GRB2-associated binding protein family. Plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11q14.1

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function: phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: osteoclast differentiation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of mast cell degranulation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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