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RPS6KA2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476601

Entrez Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated… More details

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Product Overview

Online Datasheet in PDF
Product Name
RPS6KA2, Monoclonal Antibody
Full Product Name
Anti-RPS6KA2 Mouse mAb
Product Gene Name
anti-RPS6KA2 antibody
Product Synonym Gene Name
RSK; HU-2; RSK3; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2
Product Synonym Names
RSK; HU-2; RSK3; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3C4C8
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Purified antibody in PBS with 0.05% sodium azide.
Molecular Weight
83.2
OMIM
X85106 mRNA
3D Structure
ModBase 3D Structure for Q15349
Immunogen
Purified recombinant fragment of human RPS6KA2 (AA: 415-734) expressed in E Coli.
Applications Tested/Suitable for anti-RPS6KA2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

Western Blot (WB) of anti-RPS6KA2 antibody

Western blot analysis using RPS6KA2 mAb against human RPS6KA2 (AA
Mouse Anti-RPS6KA2 Monoclonal Antibody – Cat# MBS476601

Western Blot (WB) of anti-RPS6KA2 antibody

Western blot analysis using RPS6KA2 mAb against HEK293 (1) and RPS6KA2 (AA
Mouse Anti-RPS6KA2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476601

Western Blot (WB) of anti-RPS6KA2 antibody

Western blot analysis using RPS6KA2 mouse mAb against Hela (1), A431 (2), HEK293 (3), Jurkat (4), HepG2 (5), MCF-7 (6), NIH/3T3 (7) cell lysate.
Mouse Anti-RPS6KA2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476601

Flow Cytometry (FC/FACS) of anti-RPS6KA2 antibody

Flow cytometric analysis of Hela cells using RPS6KA2 mouse mAb (green) and negative control (red).
Mouse Anti-RPS6KA2 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS476601

Immunohistochemistry (IHC) of anti-RPS6KA2 antibody

Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using RPS6KA2 mouse mAb with DAB staining.
Mouse Anti-RPS6KA2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS476601

Immunohistochemistry (IHC) of anti-RPS6KA2 antibody

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using RPS6KA2 mouse mAb with DAB staining.
Mouse Anti-RPS6KA2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS476601

Other Notes

Small volumes of anti-RPS6KA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RPS6KA2 purchase

MBS476601 is an antibody targeting RPS6KA2. Also known as Anti-RPS6KA2 Mouse mAb. Reactive in Human, Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for RPS6KA2. It may not necessarily be applicable to this product.

NCBI GI #
974576791
NCBI GeneID
6196
NCBI Accession #
NP_001305867.1
UniProt Primary Accession #
Q15349
UniProt Secondary Accession #
Q15419; Q59GJ3; Q5TI68; Q96J38; Q9UJN5; B3KTK9
UniProt Related Accession #
Q15349
GenBank Nucleotide #
NM_001318938.1
NCBI Official Full Name
ribosomal protein S6 kinase alpha-2 isoform e
NCBI Official Synonym Full Names
ribosomal protein S6 kinase A2
NCBI Official Symbol
RPS6KA2
NCBI Official Synonym Symbols
RSK; HU-2; RSK3; p90RSK2; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2
UniProt Protein Name
Ribosomal protein S6 kinase alpha-2
UniProt Synonym Protein Names
90 kDa ribosomal protein S6 kinase 2; p90-RSK 2; p90RSK2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; Ribosomal S6 kinase 3; RSK-3; pp90RSK3
Protein Family
Ribosomal protein S6 kinase
UniProt Gene Name
RPS6KA2
UniProt Synonym Gene Names
MAPKAPK1C; RSK3; S6K-alpha-2; p90-RSK 2; p90RSK2; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; RSK-3
NCBI Protein Information
ribosomal protein S6 kinase alpha-2

NCBI Summary for RPS6KA2

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
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UniProt Comments for RPS6KA2

RSK3: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6.

Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; RSK subfamily; Translation; Tumor suppressor

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: cytoplasm; cytosol; nuclear membrane; nucleoplasm; nucleus

Molecular Function: kinase activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity

Biological Process: negative regulation of cell cycle; negative regulation of cell proliferation; positive regulation of apoptosis
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Research Articles on RPS6KA2

1. RSK1 and 3 but not RSK2 are down-regulated in breast tumour and are associated with disease progression. RSK may be a key component in the progression and metastasis of breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RPS6KA2 antibody

 Reference Product  PubMed Publications
 MAPK1 antibody  >3 publications with RPS6KA2 and MAPK1
 RPS6KA1 antibody  >2 publications with RPS6KA2 and RPS6KA1
 TSC2 antibody  >1 publications with RPS6KA2 and TSC2
 MAPK3 antibody  >1 publications with RPS6KA2 and MAPK3
 RPS6 antibody  >1 publications with RPS6KA2 and RPS6

Pathways associated with anti-RPS6KA2 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Angiopoietin Like Protein 8 Regulatory Pathway antibodies  Angiopoietin Like Protein 8 Regulatory Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CREB Phosphorylation Pathway antibodies  CREB Phosphorylation Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cytoplasmic Ribosomal Proteins Pathway antibodies  Cytoplasmic Ribosomal Proteins Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram

Diseases associated with anti-RPS6KA2 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >3 publications with RPS6KA2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with RPS6KA2 and Neoplasms, Experimental
 Inflammation Antibodies  >3 publications with RPS6KA2 and Inflammation
 Prostatic Neoplasms Antibodies  >2 publications with RPS6KA2 and Prostatic Neoplasms
 Ovarian Neoplasms Antibodies  >2 publications with RPS6KA2 and Ovarian Neoplasms
 Carcinoma, Squamous Cell Antibodies  >1 publications with RPS6KA2 and Carcinoma, Squamous Cell
 Nervous System Diseases Antibodies  >1 publications with RPS6KA2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >1 publications with RPS6KA2 and Disease Models, Animal
 Infertility, Male Antibodies  >1 publications with RPS6KA2 and Infertility, Male
 Carcinoma, Hepatocellular Antibodies  >1 publications with RPS6KA2 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-RPS6KA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with RPS6KA2 and Blood
 Bone Antibodies  >2 publications with RPS6KA2 and Bone
 Mouth Antibodies  >2 publications with RPS6KA2 and Mouth
 Lymph Node Antibodies  >2 publications with RPS6KA2 and Lymph Node
 Ovary Antibodies  >2 publications with RPS6KA2 and Ovary
 Prostate Antibodies  >2 publications with RPS6KA2 and Prostate
 Embryonic Tissue Antibodies  >1 publications with RPS6KA2 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with RPS6KA2 and Pancreas
 Muscle Antibodies  >1 publications with RPS6KA2 and Muscle
 Brain Antibodies  >1 publications with RPS6KA2 and Brain
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