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C17ORF53 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476652

Entrez Summary: C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1, 200 genes.… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
C17ORF53, Monoclonal Antibody
Full Product Name
Anti-C17ORF53 Mouse mAb
Product Gene Name
anti-C17ORF53 antibody
Product Synonym Names
MODY11; MGC10442; BLK
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
1E6
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
69.8
OMIM
Z33998 mRNA
Immunogen
Purified recombinant fragment of human BLK expressed in E Coli.
Applications Tested/Suitable for anti-C17ORF53 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

Western Blot (WB) of anti-C17ORF53 antibody

Western blot analysis using C17ORF53 mAb against human C17ORF53 recombinant protein. (Expected MW is 51.9 kDa)
Mouse Anti-C17ORF53 Monoclonal Antibody – Cat# MBS476652

Western Blot (WB) of anti-C17ORF53 antibody

Western blot analysis using C17ORF53 mAb against HEK293 (1) and C17ORF53 (AA
Mouse Anti-C17ORF53 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476652

Flow Cytometry (FC/FACS) of anti-C17ORF53 antibody

Flow cytometric analysis of Jurkat cells using C17ORF53 mouse mAb (green) and negative control (purple).
Mouse Anti-C17ORF53 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS476652

Other Notes

Small volumes of anti-C17ORF53 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C17ORF53 purchase

MBS476652 is an antibody targeting C17ORF53. Also known as Anti-C17ORF53 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for C17ORF53. It may not necessarily be applicable to this product.

NCBI GI #
649143097
NCBI GeneID
640
NCBI Accession #
AIC60652.1
UniProt Secondary Accession #
Q16291; Q96IN1
UniProt Related Accession #
P51451
NCBI Official Full Name
C17orf53, partial
NCBI Official Synonym Full Names
BLK proto-oncogene, Src family tyrosine kinase
NCBI Official Symbol
BLK
NCBI Official Synonym Symbols
MODY11
UniProt Protein Name
Tyrosine-protein kinase Blk
UniProt Synonym Protein Names
B lymphocyte kinase; p55-Blk
UniProt Gene Name
BLK
NCBI Protein Information
tyrosine-protein kinase Blk

NCBI Summary for C17ORF53

This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]
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UniProt Comments for C17ORF53

BLK: a nonreceptor tyrosine kinase of the Src family. Expressed predominantly in B lymphocytes

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extrinsic to internal side of plasma membrane

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: B cell receptor signaling pathway; cell differentiation; cytoskeleton organization and biogenesis; innate immune response; negative regulation of apoptosis; positive regulation of insulin secretion; regulation of cell proliferation; regulation of phagocytosis; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Maturity-onset Diabetes Of The Young, Type 11
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Research Articles on C17ORF53

1. The systemic lupus erythematosus variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-C17ORF53 antibody

 Reference Product  PubMed Publications
 EGFR antibody  >5 publications with C17ORF53 and EGFR
 CD79B antibody  >5 publications with C17ORF53 and CD79B
 CD79A antibody  >5 publications with C17ORF53 and CD79A
 PLCG2 antibody  >3 publications with C17ORF53 and PLCG2
 CBL antibody  >2 publications with C17ORF53 and CBL
 STAT3 antibody  >1 publications with C17ORF53 and STAT3

Pathways associated with anti-C17ORF53 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 Ephrin B Reverse Signaling Pathway antibodies  Ephrin B Reverse Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram

Diseases associated with anti-C17ORF53 antibody

 Disease Name  Pubmed Publications
 Lupus Erythematosus, Systemic Antibodies  >61 publications with C17ORF53 and Lupus Erythematosus, Systemic
 Nervous System Diseases Antibodies  >36 publications with C17ORF53 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >28 publications with C17ORF53 and Cardiovascular Diseases
 Brain Diseases Antibodies  >26 publications with C17ORF53 and Brain Diseases
 Arthritis, Rheumatoid Antibodies  >26 publications with C17ORF53 and Arthritis, Rheumatoid
 Necrosis Antibodies  >23 publications with C17ORF53 and Necrosis
 Leukemia Antibodies  >23 publications with C17ORF53 and Leukemia
 Inflammation Antibodies  >22 publications with C17ORF53 and Inflammation
 Breast Neoplasms Antibodies  >11 publications with C17ORF53 and Breast Neoplasms
 Lung Diseases Antibodies  >9 publications with C17ORF53 and Lung Diseases

Organs/Tissues associated with anti-C17ORF53 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >161 publications with C17ORF53 and Blood
 Spleen Antibodies  >18 publications with C17ORF53 and Spleen
 Lung Antibodies  >16 publications with C17ORF53 and Lung
 Bone Marrow Antibodies  >16 publications with C17ORF53 and Bone Marrow
 Lymph Node Antibodies  >14 publications with C17ORF53 and Lymph Node
 Lymph Antibodies  >14 publications with C17ORF53 and Lymph
 Intestine Antibodies  >6 publications with C17ORF53 and Intestine
 Thymus Antibodies  >5 publications with C17ORF53 and Thymus
 Pancreas Antibodies  >4 publications with C17ORF53 and Pancreas
 Connective Tissue Antibodies  >3 publications with C17ORF53 and Connective Tissue
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