PDE1B Antibody – Mouse Monoclonal

FOXD3: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: nuclear chromatin; nucleoplasm

Molecular Function: protein binding; transcription factor activity

Biological Process: in utero embryonic development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance

Disease: Autoimmune Disease, Susceptibility To, 1