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GUCY1A3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476664

Entrez Summary: Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3', 5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form… More details

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Product Overview

Product Name
GUCY1A3, Monoclonal Antibody
Full Product Name
Anti-GUCY1A3 Mouse mAb
Product Gene Name
anti-GUCY1A3 antibody
Product Synonym Names
OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; MGC22487; POU5F1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
7E7
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
77.5
OMIM
X66534 mRNA
3D Structure
ModBase 3D Structure for Q02108
Immunogen
Synthesized peptide derived from internal of human Oct4.
Applications Tested/Suitable for anti-GUCY1A3 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

Western Blot (WB) of anti-GUCY1A3 antibody

Western blot analysis using GUCY1A3 mAb against human GUCY1A3 recombinant protein. (Expected MW is 47.2 kDa)
Mouse Anti-GUCY1A3 Monoclonal Antibody – Cat# MBS476664

Western Blot (WB) of anti-GUCY1A3 antibody

Western blot analysis using GUCY1A3 mAb against HEK293 (1) and GUCY1A3 (AA
Mouse Anti-GUCY1A3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476664

Western Blot (WB) of anti-GUCY1A3 antibody

Western blot analysis using GUCY1A3 mouse mAb against HEK293 (1) and Jurkat (2) cell lysate.
Mouse Anti-GUCY1A3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476664

Immunofluorescence (IF) of anti-GUCY1A3 antibody

Immunofluorescence analysis of HepG2 cells using GUCY1A3 mouse mAb (green). Blue
Mouse Anti-GUCY1A3 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS476664

Flow Cytometry (FC/FACS) of anti-GUCY1A3 antibody

Flow cytometric analysis of HEK293 cells using GUCY1A3 mouse mAb (green) and negative control (purple).
Mouse Anti-GUCY1A3 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS476664

Immunohistochemistry (IHC) of anti-GUCY1A3 antibody

Immunohistochemical analysis of paraffin-embedded renal cancer tissues using GUCY1A3 mouse mAb with DAB staining.
Mouse Anti-GUCY1A3 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS476664

Immunohistochemistry (IHC) of anti-GUCY1A3 antibody

Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using GUCY1A3 mouse mAb with DAB staining.
Mouse Anti-GUCY1A3 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS476664

Other Notes

Small volumes of anti-GUCY1A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GUCY1A3 purchase

MBS476664 is an antibody targeting GUCY1A3. Also known as Anti-GUCY1A3 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GUCY1A3. It may not necessarily be applicable to this product.

NCBI GI #
194595474
NCBI GeneID
2982
NCBI Accession #
NP_001124155.1
UniProt Primary Accession #
Q02108
UniProt Secondary Accession #
O43843; Q8TAH3; D3DP19; D6RDW3
UniProt Related Accession #
Q02108
GenBank Nucleotide #
NM_001130683.3
NCBI Official Full Name
guanylate cyclase soluble subunit alpha-3 isoform A
NCBI Official Synonym Full Names
guanylate cyclase 1 soluble subunit alpha
NCBI Official Symbol
GUCY1A3
NCBI Official Synonym Symbols
GUCA3; MYMY6; GC-SA3; GUC1A3; GUCSA3; GUCY1A1
UniProt Protein Name
Guanylate cyclase soluble subunit alpha-3
UniProt Synonym Protein Names
GCS-alpha-1; Soluble guanylate cyclase large subunit
Protein Family
Guanylate cyclase soluble
UniProt Gene Name
GUCY1A3
UniProt Synonym Gene Names
GUC1A3; GUCSA3; GUCY1A1; GCS-alpha-3
NCBI Protein Information
guanylate cyclase soluble subunit alpha-3

NCBI Summary for GUCY1A3

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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UniProt Comments for GUCY1A3

GUCY1A3: Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Protein type: EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc.

Chromosomal Location of Human Ortholog: 4q32.1

Cellular Component: guanylate cyclase complex, soluble; plasma membrane

Molecular Function: adenylate cyclase activity; guanylate cyclase activity; protein binding; receptor activity

Biological Process: blood circulation; cGMP biosynthetic process; nitric oxide mediated signal transduction

Disease: Moyamoya Disease 6 With Achalasia
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Research Articles on GUCY1A3

1. Expression of the alpha1-A680T sGC variant in reporter cells resulted in higher cyclic guanosine monophosphate production compared with the wild-type enzyme and the purified alpha1-A680T sGC exhibited enhanced sensitivity to nitric oxide in vitro.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GUCY1A3 antibody

 Reference Product  PubMed Publications
 GUCY1B3 antibody  >6 publications with GUCY1A3 and GUCY1B3
 NOS3 antibody  >2 publications with GUCY1A3 and NOS3
 PDE6A antibody  >1 publications with GUCY1A3 and PDE6A
 PDE5A antibody  >1 publications with GUCY1A3 and PDE5A

Pathways associated with anti-GUCY1A3 antibody

 Products by Pathway  Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies  Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram

Diseases associated with anti-GUCY1A3 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >7 publications with GUCY1A3 and Hypertension
 Coronary Artery Disease Antibodies  >6 publications with GUCY1A3 and Coronary Artery Disease
 Heart Diseases Antibodies  >6 publications with GUCY1A3 and Heart Diseases
 Brain Diseases Antibodies  >2 publications with GUCY1A3 and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with GUCY1A3 and Nervous System Diseases
 Kidney Diseases Antibodies  >1 publications with GUCY1A3 and Kidney Diseases
 Lung Diseases Antibodies  >1 publications with GUCY1A3 and Lung Diseases
 Edema Antibodies  >1 publications with GUCY1A3 and Edema
 Inflammation Antibodies  >1 publications with GUCY1A3 and Inflammation
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with GUCY1A3 and Prenatal Exposure Delayed Effects

Organs/Tissues associated with anti-GUCY1A3 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >8 publications with GUCY1A3 and Heart
 Brain Antibodies  >6 publications with GUCY1A3 and Brain
 Vascular Antibodies  >4 publications with GUCY1A3 and Vascular
 Kidney Antibodies  >3 publications with GUCY1A3 and Kidney
 Muscle Antibodies  >2 publications with GUCY1A3 and Muscle
 Liver Antibodies  >2 publications with GUCY1A3 and Liver
 Prostate Antibodies  >2 publications with GUCY1A3 and Prostate
 Nerve Antibodies  >1 publications with GUCY1A3 and Nerve
 Lung Antibodies  >1 publications with GUCY1A3 and Lung
 Embryonic Tissue Antibodies  >1 publications with GUCY1A3 and Embryonic Tissue
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