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DCTN4 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476667

Entrez Summary: Dynactin 4 could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Product Overview

Product Name
DCTN4, Monoclonal Antibody
Full Product Name
Anti-DCTN4 Mouse mAb
Product Gene Name
anti-DCTN4 antibody
Product Synonym Names
CHTD2; FLJ21885; KIAA0733; MAP3K7IP2; TAB2
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3B5
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Molecular Weight
52.3
OMIM
AF195120 mRNA
3D Structure
ModBase 3D Structure for Q9UJW0
Immunogen
Purified recombinant fragment of human TAB2 expressed in E Coli.
Applications Tested/Suitable for anti-DCTN4 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

Western Blot (WB) of anti-DCTN4 antibody

Western blot analysis using DCTN4 mAb against human DCTN4 recombinant protein. (Expected MW is 53.2 kDa)
Mouse Anti-DCTN4 Monoclonal Antibody – Cat# MBS476667

Western Blot (WB) of anti-DCTN4 antibody

Western blot analysis using DCTN4 mAb against HEK293 (1) and DCTN4 (AA
Mouse Anti-DCTN4 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476667

Western Blot (WB) of anti-DCTN4 antibody

Western blot analysis using DCTN4 mouse mAb against Raw264.7 (1) and NIH3T3 (2) cell lysate.
Mouse Anti-DCTN4 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476667

Immunofluorescence (IF) of anti-DCTN4 antibody

Immunofluorescence analysis of HepG2 cells using DCTN4 mouse mAb (green). Blue
Mouse Anti-DCTN4 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS476667

Flow Cytometry (FC/FACS) of anti-DCTN4 antibody

Flow cytometric analysis of HEK293 cells using DCTN4 mouse mAb (green) and negative control (red).
Mouse Anti-DCTN4 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS476667

Immunohistochemistry (IHC) of anti-DCTN4 antibody

Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using DCTN4 mouse mAb with DAB staining.
Mouse Anti-DCTN4 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS476667

Immunohistochemistry (IHC) of anti-DCTN4 antibody

Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using DCTN4 mouse mAb with DAB staining.
Mouse Anti-DCTN4 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS476667

Other Notes

Small volumes of anti-DCTN4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DCTN4 purchase

MBS476667 is an antibody targeting DCTN4. Also known as Anti-DCTN4 Mouse mAb. Reactive in Human, Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DCTN4. It may not necessarily be applicable to this product.

NCBI GI #
208431795
NCBI GeneID
51164
NCBI Accession #
NP_001129116.1
UniProt Primary Accession #
Q9UJW0
UniProt Secondary Accession #
Q8TAN8; B3KWW0; D3DQH0; E5RGT5
UniProt Related Accession #
Q9UJW0
GenBank Nucleotide #
NM_001135644.1
NCBI Official Full Name
dynactin subunit 4 isoform c
NCBI Official Synonym Full Names
dynactin subunit 4
NCBI Official Symbol
DCTN4
NCBI Official Synonym Symbols
P62; DYN4
UniProt Protein Name
Dynactin subunit 4
UniProt Synonym Protein Names
Dynactin subunit p62
Protein Family
Dynactin
UniProt Gene Name
DCTN4
UniProt Synonym Gene Names
Dyn4
NCBI Protein Information
dynactin subunit 4

UniProt Comments for DCTN4

dynactin 4: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. Belongs to the dynactin subunit 4 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: centrosome; cytoplasm; cytoplasmic dynein complex; cytosol; dynactin complex; nucleus

Molecular Function: protein binding; protein N-terminus binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; ER to Golgi vesicle-mediated transport; nuclear migration
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Research Articles on DCTN4

1. used an extreme phenotype study to discover that variants in DCTN4, encoding a dynactin protein, are associated with time to first P. aeruginosa airway infection, chronic P. aeruginosa infection and mucoid P. aeruginosa in individuals with cystic fibrosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DCTN4 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
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 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
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Diseases associated with anti-DCTN4 antibody

 Disease Name  Pubmed Publications
 Pseudomonas Infections Antibodies  >1 publications with DCTN4 and Pseudomonas Infections
 Cystic Fibrosis Antibodies  >1 publications with DCTN4 and Cystic Fibrosis

Organs/Tissues associated with anti-DCTN4 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with DCTN4 and Liver
 Heart Antibodies  >1 publications with DCTN4 and Heart
 Blood Antibodies  >1 publications with DCTN4 and Blood
 Lung Antibodies  >1 publications with DCTN4 and Lung
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