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CTNNBL1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS476769

Entrez Summary: The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is… More details

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Product Overview

Online Datasheet in PDF
Product Name
CTNNBL1, Monoclonal Antibody
Full Product Name
Anti-CTNNBL1 Mouse mAb
Product Gene Name
anti-CTNNBL1 antibody
Product Synonym Gene Name
NAP; P14L; PP8304; C20orf33; dJ633O20.1
Product Synonym Names
5730471K09Rik; Beta catenin like 1; Beta catenin like protein 1; Beta-catenin-like protein 1; C20orf33; Cadherin associated protein; Catenin beta like 1; Chromosome 20 open reading frame 3; CTBL1_HUMAN; CTNN protein; CTNNBL 1; Ctnnbl1; dJ633O20.1; FLJ21108; NAP; Nuclear associated protein; nuclear protein NAP; Nuclear-associated protein; NYD SP19; OTTMUSP00000016933; P14; P14L; PP8304; RP5 1118M15.1; Testis development protein NYD SP19; Testis development protein NYD-SP19
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
7H6-B4-A8
Host
Mouse
Species Reactivity
Human
Form/Format
Purified antibody in PBS with 0.05% sodium azide.
Molecular Weight
65kDa
OMIM
AF239607 mRNA
3D Structure
ModBase 3D Structure for Q8WYA6
Immunogen
Purified recombinant fragment of human CTNNBL1 (AA: 390-557) expressed in E Coli.
Sequence Similarities
Contains 2 HEAT repeats.
Subunit Structure
Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2.
Subcellular Location
Cytoplasm
Applications Tested/Suitable for anti-CTNNBL1 antibody
Western Blot (WB)

Western Blot (WB) of anti-CTNNBL1 antibody

Western blot detection of CTNNBL1 in A549, MCF7 and Hela cell lysates using CTNNBL1 mouse mAb (1:500 diluted).Predicted band size:65KDa.Observed band size:65KDa.
Mouse Anti-CTNNBL1 Monoclonal Antibody – Cat# MBS476769

Western Blot (WB) of anti-CTNNBL1 antibody

Western blot analysis using CTNNBL1 mAb against HEK293 (1) and CTNNBL1 (AA
Mouse Anti-CTNNBL1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS476769

Flow Cytometry (FC/FACS) of anti-CTNNBL1 antibody

Flow cytometric analysis of Hela cells using CTNNBL1 mouse mAb (green) and negative control (red).
Mouse Anti-CTNNBL1 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS476769

Other Notes

Small volumes of anti-CTNNBL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTNNBL1 purchase

MBS476769 is an antibody targeting CTNNBL1. Also known as Anti-CTNNBL1 Mouse mAb. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CTNNBL1. It may not necessarily be applicable to this product.

NCBI GI #
527498276
NCBI GeneID
56259
NCBI Accession #
NP_001268424.1
UniProt Primary Accession #
Q8WYA6
UniProt Secondary Accession #
Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; B4DE16
UniProt Related Accession #
Q8WYA6
GenBank Nucleotide #
NM_001281495.1
NCBI Official Full Name
beta-catenin-like protein 1 isoform 2
NCBI Official Synonym Full Names
catenin beta like 1
NCBI Official Symbol
CTNNBL1
NCBI Official Synonym Symbols
NAP; P14L; PP8304; C20orf33; dJ633O20.1
UniProt Protein Name
Beta-catenin-like protein 1
UniProt Synonym Protein Names
Nuclear-associated protein; NAP; Testis development protein NYD-SP19
Protein Family
Beta-catenin-like protein
UniProt Gene Name
CTNNBL1
UniProt Synonym Gene Names
C20orf33; NAP
NCBI Protein Information
beta-catenin-like protein 1

NCBI Summary for CTNNBL1

The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]
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UniProt Comments for CTNNBL1

CTNNBL1: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; Spliceosome

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: membrane; nucleoplasm; nucleus; spliceosome

Molecular Function: enzyme binding; protein binding

Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of apoptosis; somatic diversification of immunoglobulins
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Research Articles on CTNNBL1

1. Tthis study identified WNT5B and CTNNBL1 for peak bone mineral density and body composition in males from the Han Chinese ethnic group.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CTNNBL1 antibody

 Products by Pathway  Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome, Prp19/CDC5L Complex Pathway antibodies  Spliceosome, Prp19/CDC5L Complex Pathway Diagram

Diseases associated with anti-CTNNBL1 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >1 publications with CTNNBL1 and Death
 Genetic Predisposition to Disease Antibodies  >1 publications with CTNNBL1 and Genetic Predisposition to Disease
 Kidney Diseases Antibodies  >1 publications with CTNNBL1 and Kidney Diseases
 Urologic Neoplasms Antibodies  >1 publications with CTNNBL1 and Urologic Neoplasms
 Kidney Neoplasms Antibodies  >1 publications with CTNNBL1 and Kidney Neoplasms
 Neoplasms Antibodies  >1 publications with CTNNBL1 and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with CTNNBL1 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-CTNNBL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with CTNNBL1 and Bone
 Heart Antibodies  >1 publications with CTNNBL1 and Heart
 Kidney Antibodies  >1 publications with CTNNBL1 and Kidney
 Spleen Antibodies  >1 publications with CTNNBL1 and Spleen
 Eye Antibodies  >1 publications with CTNNBL1 and Eye
 Liver Antibodies  >1 publications with CTNNBL1 and Liver
 Brain Antibodies  >1 publications with CTNNBL1 and Brain
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