CSNK2B Antibody – Mouse Monoclonal

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

CK2B: a regulatory subunit of the casein kinase 2 holoenzyme. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. Plays a complex role in regulating the basal catalytic activity of the alpha subunit. Participates in Wnt signaling

Protein type: Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 6p21.33

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; PcG protein complex; plasma membrane; protein kinase CK2 complex

Molecular Function: chromatin binding; identical protein binding; protein binding; protein domain specific binding; protein kinase regulator activity; protein serine/threonine kinase activity; receptor binding; transcription factor binding

Biological Process: adiponectin-mediated signaling pathway; negative regulation of blood vessel endothelial cell migration; negative regulation of cell proliferation; positive regulation of activin receptor signaling pathway; protein folding; signal transduction