NME2 Antibody – Mouse Monoclonal

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.13.3; EC 2.7.4.6; Kinase, nucleoside diphosphate; Kinase, other; NDK family; Nuclear receptor co-regulator; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other group

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: cytoplasm; cytosol; focal adhesion; lamellipodium; nucleus; ruffle

Molecular Function: nucleoside diphosphate kinase activity; protein binding; transcription factor activity

Biological Process: cell adhesion; integrin-mediated signaling pathway; negative regulation of apoptosis; nucleobase, nucleoside and nucleotide interconversion; nucleoside triphosphate biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; purine nucleotide metabolic process; pyrimidine nucleotide metabolic process; regulation of epidermis development; regulation of transcription, DNA-dependent