HH3 Antibody – Mouse Monoclonal

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.

Protein type: EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group

Chromosomal Location of Human Ortholog: 20q11.21

Cellular Component: actin filament; caveola; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; lysosome

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: cell adhesion; cell differentiation; cytokine and chemokine mediated signaling pathway; innate immune response-activating signal transduction; integrin-mediated signaling pathway; leukocyte degranulation; leukocyte migration during immune response; lipopolysaccharide-mediated signaling pathway; mesoderm development; negative regulation of apoptosis; peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell proliferation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell shape; regulation of defense response to virus by virus; regulation of inflammatory response; regulation of phagocytosis; regulation of transcription factor activity; respiratory burst after phagocytosis; transmembrane receptor protein tyrosine kinase signaling pathway