MAP3K7 Antibody – Mouse Monoclonal

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

TAK1: a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described.

Protein type: EC 2.7.11.25; Kinase, protein; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TAK1 subfamily; TKL group

Chromosomal Location of Human Ortholog: 6q15

Cellular Component: cytoplasm; cytosol; endosome membrane; IkappaB kinase complex; nucleus

Molecular Function: identical protein binding; MAP kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: activation of MAPK activity; activation of MAPKK activity; activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; I-kappaB kinase/NF-kappaB cascade; I-kappaB phosphorylation; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 production; positive regulation of JNK activity; positive regulation of T cell activation; positive regulation of T cell cytokine production; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; transforming growth factor beta receptor signaling pathway; Wnt receptor signaling pathway, calcium modulating pathway

Disease: Cardiospondylocarpofacial Syndrome; Frontometaphyseal Dysplasia 2