TIP60 Antibody – Mouse Monoclonal

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.

Protein type: Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus

Molecular Function: acetyltransferase activity; histone acetyltransferase activity; protein binding; transcription coactivator activity

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA double-strand break processing; DNA replication; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; histone acetylation; negative regulation of interleukin-2 production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; response to ionizing radiation; strand displacement