WTAP Antibody – Mouse Monoclonal

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

DYN1: a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain.

Protein type: EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: mitochondrial membrane; plasma membrane

Molecular Function: identical protein binding; microtubule binding; protein binding; protein kinase binding

Biological Process: endocytosis; endosome organization and biogenesis; ephrin receptor signaling pathway; mitochondrial fission; receptor internalization; receptor-mediated endocytosis

Disease: Epileptic Encephalopathy, Early Infantile, 31