SRC Antibody – Rabbit Polyclonal

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Src: proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme. Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: caveola; cell-cell adherens junction; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; late endosome; lysosome; mitochondrial inner membrane; mitochondrion; plasma membrane

Molecular Function: enzyme binding; ephrin receptor binding; heme binding; hormone receptor binding; integrin binding; kinase activity; kinase binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; receptor binding; SH2 domain binding; SH3/SH2 adaptor activity

Biological Process: bone resorption; central nervous system development; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; estrogen receptor signaling pathway; innate immune response; integrin-mediated signaling pathway; leukocyte migration; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of focal adhesion formation; negative regulation of mitochondrial depolarization; negative regulation of protein homooligomerization; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; peptidyl-tyrosine phosphorylation; platelet activation; platelet-derived growth factor receptor signaling pathway; positive regulation of integrin activation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of small GTPase mediated signal transduction; progesterone receptor signaling pathway; protein amino acid autophosphorylation; regulation of bone resorption; regulation of cell cycle; regulation of cell proliferation; regulation of cell-cell adhesion; regulation of vascular permeability; signal complex assembly; signal transduction; stimulatory C-type lectin receptor signaling pathway; stress fiber formation; T cell costimulation; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway

Disease: Colorectal Cancer; Thrombocytopenia 6